(2-Propionyl-phenyl)-propargylether | 60505-20-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-Propionyl-phenyl)-propargylether
• 英文别名: 1-(2-Prop-2-ynoxyphenyl)propan-1-one
• CAS: 60505-20-6
• 化学式: C₁₂H₁₂O₂
• mdl: MFCD09936635
• 分子量: 188.226
• InChiKey: DRAIEWOSFQRTEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-Propionyl-phenyl)-propargylether 、 依达拉奉 在 乙酸–三乙胺 、 zinc(II) oxide 作用下， 反应 7.0h， 以32%的产率得到(11bS)-11b-ethyl-3,11b-dihydro-1-methyl-3-phenyl-6H-chromeno[4',3':4,5]pyrano[2,3-c]pyrazole
  参考文献：
  名称：

  Triethylammonium acetate-mediated domino-Knoevenagel-hetero-Diels–Alder reaction: synthesis of some angular polyheterocycles

  摘要：

  A solvent-cum catalyst, ionic liquid triethylammonium acetate-mediated one-pot procedure for the synthesis of some new angular benzopyrano[3,4-c]pyrano-fused pyrazoles, all of which incorporate a tertiary ring junction carbon, has been developed. The stereochemistry of the products has been confirmed by single-crystal X-ray diffraction data.

  DOI：

  10.1007/s00706-012-0873-7
• 作为产物：
  描述：

  2'-羟基苯丙酮 、 3-溴丙炔 在 potassium carbonate 作用下， 生成 (2-Propionyl-phenyl)-propargylether
  参考文献：
  名称：

  衍生品3-烷基-1-苯并二甲苯基-2-和2-烷基-1，4-萘甲酮2-酰基芳基-炔丙基酯†

  摘要：

  来自2-酰基芳基炔丙基醚的3-烷基-1-苯并氧杂-5-酮衍生物和2-烷基-1,4-萘醌。

  DOI：

  10.1002/hlca.19760590233

文献信息

• Gold-Catalyzed Synthesis of Polycyclic Enones from Carbon Tethered 1,3-Enynyl Carbonyls via Tandem Heteroenyne Metathesis and Nazarov Reaction
  作者：Tienan Jin、Yoshinori Yamamoto

  DOI：10.1021/ol801265s

  日期：2008.7.17

  An efficient and general Au(III)-catalyzed tandem reaction, heteroenyne metathesis and Nazarov cyclization, of 1,3-enynyl ketones to produce fused tri- and tetracyclic enones has been developed. The products were formed with excellent regioselectivity of the double bond position and with very high diastereoselectivities. In this reaction, the Au(III) catalyst exhibits dual roles for activating both alkynes and carbonyls.
• Triethylammonium acetate-mediated domino-Knoevenagel-hetero-Diels–Alder reaction: synthesis of some angular polyheterocycles
  作者：Narsidas J. Parmar、Bhavesh R. Pansuriya、Hitesh A. Barad、Bhagyashri D. Parmar、Rajni Kant、Vivek K. Gupta

  DOI：10.1007/s00706-012-0873-7

  日期：2013.6

  A solvent-cum catalyst, ionic liquid triethylammonium acetate-mediated one-pot procedure for the synthesis of some new angular benzopyrano[3,4-c]pyrano-fused pyrazoles, all of which incorporate a tertiary ring junction carbon, has been developed. The stereochemistry of the products has been confirmed by single-crystal X-ray diffraction data.
• 3-Alkyl-1-benzoxepin-5-on-Derivate und 2-Alkyl-1, 4-naphthochinone aus 2-Acylaryl-propargyläthern
  作者：Martha Jackson-Mülly、Janos Zsindely、Hans Schmid

  DOI：10.1002/hlca.19760590233

  日期：1976.3.10

  3-Alkyl-1-benzoxepin-5-one derivatives and 2-alkyl-1,4-naphtoquinones from 2-acylaryl propargyl ethers.

  来自2-酰基芳基炔丙基醚的3-烷基-1-苯并氧杂-5-酮衍生物和2-烷基-1,4-萘醌。