4-aminobutyryl p-nitrophenyl ester | 87880-80-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-aminobutyryl p-nitrophenyl ester
• 英文别名: GABA-OPNP；(4-Nitrophenyl) 4-aminobutanoate
• CAS: 87880-80-6
• 化学式: C₁₀H₁₂N₂O₄
• 分子量: 224.216
• InChiKey: NLWNFKPIPBTODX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  98.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-aminobutyryl p-nitrophenyl ester 、 O-benzyl-PhTX-343 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of glutamate receptor antagonist philanthotoxin-433 (PhTX-433) and its analogs

  摘要：

  DOI：

  10.1016/s0040-4020(01)85463-6
• 作为产物：
  描述：

  4-nitrophenyl 4-{[(benzyloxy)carbonyl]amino}butanoate 在 氢溴酸 、 溶剂黄146 作用下， 生成 4-aminobutyryl p-nitrophenyl ester
  参考文献：
  名称：

  Matsui,T.; Koga,K., Chemical and pharmaceutical bulletin, 1979, vol. 27, p. 2295 - 2303

  摘要：

  DOI：

文献信息

• Mapping of the active site of rat kidney γ-glutamyl transpeptidase using activated esters and their amide derivatives
  作者：Roselyne Castonguay、Christian Lherbet、Jeffrey W Keillor

  DOI：10.1016/s0968-0896(02)00165-7

  日期：2002.12

  usually an amino acid or a peptide. In order to investigate which moieties of the donor substrate are necessary for recognition by GGT, the structure of the well-recognized substrate L-gamma-glutamyl-p-nitroanilide was modified. Several activated esters and their amide derivatives were synthesized and used as substrates. Kinetic (K(m) and V(max)) and inhibition constants (K(i)) were measured and reveal

  涉及许多生理过程的酶γ-谷氨酰转肽酶（GGT）催化γ-谷氨酰基从供体底物向酰基受体底物（通常是氨基酸或肽）的转移。为了研究供体底物的哪​​些部分对于通过GGT识别是必需的，对公认的底物L-γ-谷氨酰基-对硝基苯胺的结构进行了修饰。合成了几种活化的酯及其酰胺衍生物，并用作底物。测量了动力学（K（m）和V（max））和抑制常数（K（i）），结果表明，几乎整个γ-谷氨酰基部分对于识别供体底物的结合位点都是必需的。
• ACRYLAMIDE DERIVATIVES AND POLYMERS CONTAINING SAID DERIVATIVES
  申请人：Amersham Pharmacia Biotech K.K.

  公开号：EP1147076A1

  公开（公告）日：2001-10-24
• [EN] ACRYLAMIDE DERIVATIVES AND POLYMERS CONTAINING SAID DERIVATIVES<br/>[FR] DÉRIVÉS D'ACRYLAMIDE ET POLYMÈRES CONTENANT LESDITS DÉRIVÉS
  申请人：AMERSHAM PHARMACIA BIOTECH K K

  公开号：WO2000043355A1

  公开（公告）日：2000-07-27

  An acrylamide derivative of general formula (I) is used to prepare a polymer or copolymer: wherein R1 represents a hydrogen atom, a straight-chain or branched alkyl group containing 1 to 4 carbon atoms or a C3-6 cycloalkyl group, R?2 and R3¿ each independently represent an alkylene group containing 1 to 6 carbon atoms or R?2 and R3¿ may be combined to form a ring, X represents a hydrogen atom, an amino group, a hydroxyl group, a halogen atom, a carboxyl group or a -COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group, and Y represents an amino group, a halogen atom, a carboxyl group or a -COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group. The thus obtained polymer or copolymer is a polymer or hydrogel incorporating many functional groups while maintaining the sensitive temperature response.
• Synthesis of glutamate receptor antagonist philanthotoxin-433 (PhTX-433) and its analogs
  作者：R. Goodnow、K. Konno、M. Niwa、T. Kallimopoulos、R. Bukownik、Deborah Lenares、K. Nakanishi

  DOI：10.1016/s0040-4020(01)85463-6

  日期：——
• Matsui,T.; Koga,K., Chemical and pharmaceutical bulletin, 1979, vol. 27, p. 2295 - 2303
  作者：Matsui,T.、Koga,K.

  DOI：——

  日期：——