1-[ethyl-(2-amino-ethyl)-amino]-2-methyl-propan-2-ol | 51387-97-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[ethyl-(2-amino-ethyl)-amino]-2-methyl-propan-2-ol
• 英文别名: 1-[Aethyl-(2-amino-aethyl)-amino]-2-methyl-propan-2-ol；1-[2-Aminoethyl(ethyl)amino]-2-methylpropan-2-ol；1-[2-aminoethyl(ethyl)amino]-2-methylpropan-2-ol
• CAS: 51387-97-4
• 化学式: C₈H₂₀N₂O
• 分子量: 160.26
• InChiKey: UQWCWIDMAWKPCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-氯-3-(3,4-二氯苯基)-3,4-二氢-10-羟基-1,9-(2H,10H)-吖啶二酮 、 1-[ethyl-(2-amino-ethyl)-amino]-2-methyl-propan-2-ol 以 乙醇 为溶剂， 反应 1.5h， 以96%的产率得到7-Chloro-3-(3,4-dichloro-phenyl)-1-{(E)-2-[ethyl-(2-hydroxy-2-methyl-propyl)-amino]-ethylimino}-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one
  参考文献：
  名称：

  Antimalarial drugs. 64. Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures

  摘要：

  To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-[(alkylamino)alkylene]imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates. Among structural modifications prepared, including N-10-alkyl and C2-substituted analogs, removal of the C-9 oxygen, and introduction of an imino side chain at C-9, the imines of the N-10-H acridinediones were the most active compounds obtained. The [3-(NN-dimethylamino)propyl]imino derivative of 7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.

  DOI：

  10.1021/jm00097a001
• 作为产物：
  描述：

  N-(2-溴乙基)邻苯二甲酰亚胺 、 1-乙基氨基-2-甲基丙烷-2-醇 在 xylene 作用下， 生成 1-[ethyl-(2-amino-ethyl)-amino]-2-methyl-propan-2-ol
  参考文献：
  名称：

  The Preparation of Some 1-Alkylamino- and Dialkylaminoalkylaminothiaxanthones¹

  摘要：

  DOI：

  10.1021/ja01137a017

文献信息

• Alkylaminoalkylamino Derivatives of Xanthones, Acridones and Anthraquinones
  作者：S. Archer、Lois B. Rochester、Mary Jackman

  DOI：10.1021/ja01631a077

  日期：1954.1
• 1-(hydroxylakylaminoalkylamino)-4-methylxanthones and their preparation
  申请人：STERLING DRUG INC

  公开号：US02631154A1

  公开（公告）日：1953-03-10
• HYDROGEN SULPHIDE AND MERCAPTANS SCAVENGING COMPOSITIONS
  申请人：Total Marketing Services

  公开号：EP3891260A1

  公开（公告）日：2021-10-13
• [EN] HYDROGEN SULPHIDE AND MERCAPTANS SCAVENGING COMPOSITIONS<br/>[FR] COMPOSITIONS DE PIÉGEAGE DU SULFURE D'HYDROGÈNE ET DE MERCAPTANS
  申请人：TOTAL MARKETING SERVICES

  公开号：WO2020115132A1

  公开（公告）日：2020-06-11

  The present invention relates to a composition for scavenging hydrogen sulphide and/or mercaptans in hydrocarbon streams, the composition comprising an oxazolidine compound and a synergistic additive.
• Antimalarial drugs. 64. Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures
  作者：Stephen J. Kesten、Margaret J. Degnan、Jocelyn Hung、Dennis J. McNamara、Daniel F. Ortwine、Susan E. Uhlendorf、Leslie M. Werbel

  DOI：10.1021/jm00097a001

  日期：1992.9

  To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-[(alkylamino)alkylene]imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates. Among structural modifications prepared, including N-10-alkyl and C2-substituted analogs, removal of the C-9 oxygen, and introduction of an imino side chain at C-9, the imines of the N-10-H acridinediones were the most active compounds obtained. The [3-(NN-dimethylamino)propyl]imino derivative of 7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.