p-<(t-butyldimethylsiloxy)methyl>phenyl methyl ketone | 93131-87-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-<(t-butyldimethylsiloxy)methyl>phenyl methyl ketone
• 英文别名: 1-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl]ethanone；1-[4-[[tert-butyl(dimethyl)silyl]oxymethyl]phenyl]ethanone
• CAS: 93131-87-4
• 化学式: C₁₅H₂₄O₂Si
• 分子量: 264.44
• InChiKey: WVYZTMYTEYCCCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.41
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  p-<(t-butyldimethylsiloxy)methyl>phenyl methyl ketone 在 四丁基氟化铵 作用下， 以 二氯甲烷 为溶剂， 生成 4-(羟基甲基)苯乙酮
  参考文献：
  名称：

  用于醇选择性氧化的氟铬酸吡啶鎓或氯铬酸苄基三甲基铵

  摘要：

  在伯醇存在下仲醇的选择性氧化已通过以下顺序实现，(1) 用 t-BuMe2SiCl 选择性保护伯醇，(2) 用标题试剂氧化仲醇，以及 (3) 伯醇的脱保护羟基。

  DOI：

  10.1246/bcsj.57.2019
• 作为产物：
  描述：

  4-(1-羟乙基)苄醇 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 p-<(t-butyldimethylsiloxy)methyl>phenyl methyl ketone
  参考文献：
  名称：

  用于醇选择性氧化的氟铬酸吡啶鎓或氯铬酸苄基三甲基铵

  摘要：

  在伯醇存在下仲醇的选择性氧化已通过以下顺序实现，(1) 用 t-BuMe2SiCl 选择性保护伯醇，(2) 用标题试剂氧化仲醇，以及 (3) 伯醇的脱保护羟基。

  DOI：

  10.1246/bcsj.57.2019

文献信息

• AMIDINE COMPOUND OR SALT THEREOF
  申请人：Tanikawa Tetsuya

  公开号：US20140155597A1

  公开（公告）日：2014-06-05

  The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus Candida , the genus Aspergillus and the genus Trichophyton and is useful as a medicinal agent. A compound represented by formula (I) (wherein A 1 represents a nitrogen atom or a group represented by formula CR 6 ; A 2 and A 3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; R 1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; R 2 and R 3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a C 1-6 haloalkyl group or a C 1-6 alkoxy group; and R 4 and R 5 are the same as or different from each other and independently represent a hydrogen atom, a C 1-6 haloalkyl group, a C 1-6 alkyl group or the like) or a salt thereof is useful as an anti-fungal agent.

  本发明的目的是提供一种新颖的化合物，该化合物对包括属于念珠菌属、曲霉属和毛癣菌属的病原真菌具有抗真菌活性，并可用作药物。由公式(I) (其中A 1代表氮原子或由公式CR 6表示的基团；A 2和A 3相同或不同，独立地表示氮原子或由公式CH表示的基团；R 1表示可能由1至5个独立选自取代基组(2)的取代基取代的芳基；R 2和R 3相同或不同，独立地表示氢原子、卤素原子、C 1-6烷基、C 1-6卤代烷基或C 1-6烷氧基；R 4和R 5相同或不同，独立地表示氢原子、C 1-6卤代烷基、C 1-6烷基等)或其盐用作抗真菌剂。
• Amidine compound or salt thereof
  申请人：Tanikawa Tetsuya

  公开号：US09045466B2

  公开（公告）日：2015-06-02

  An amidine compound represented by formula (I) (wherein A1 represents a nitrogen atom or a group represented by formula CR6; A2 and A3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; R1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; R2 and R3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group or a C1-6 alkoxy group; and R4 and R5 are the same as or different from each other and independently represent a hydrogen atom, a C1-6 haloalkyl group, a C1-6 alkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.

  一种由公式(I)表示的氨基甲酸化合物（其中A1表示氮原子或由公式CR6表示的基团；A2和A3相同或不同，且独立地表示氮原子或由公式CH表示的基团；R1表示芳基基团，该基团可以被1至5个独立选择的取代基（2）或类似物取代；R2和R3相同或不同，且独立地表示氢原子、卤素原子、C1-6烷基、C1-6卤代烷基或C1-6烷氧基；R4和R5相同或不同，且独立地表示氢原子、C1-6卤代烷基、C1-6烷基或类似物）或其盐。该化合物可用作抗真菌剂。
• Direct synthesis of carbonyl compounds from THP ethers with IBX in the presence of β-cyclodextrin in water
  作者：M. Narender、M. Somi Reddy、V. Pavan Kumar、Y.V.D. Nageswar、K. Rama Rao

  DOI：10.1016/j.tetlet.2005.02.002

  日期：2005.3

  Water, an environmentally friendly reaction medium, has been utilized for the oxidative deprotection of tetrahydropyranyl ethers 1 with lBX at room temperature in the presence of beta-cyclodextrin to give the corresponding carbonyl compounds 2. (C) 2005 Elsevier Ltd. All rights reserved.
• NONAKA, TSUYOSHI;KANEMOTO, SHIGEKAZU;OSHIMA, KOICHIRO;NOZAKI, HITOSI, BULL. CHEM. SOC. JAP., 1984, 57, N 7, 2019-2020
  作者：NONAKA, TSUYOSHI、KANEMOTO, SHIGEKAZU、OSHIMA, KOICHIRO、NOZAKI, HITOSI

  DOI：——

  日期：——
• Pyridinium Fluorochromate or Benzyltrimethylammonium Chlorochromate for Selective Oxidation of Alcohols
  作者：Tsuyoshi Nonaka、Shigekazu Kanemoto、Koichiro Oshima、Hitosi Nozaki

  DOI：10.1246/bcsj.57.2019

  日期：1984.7

  Selective oxidation of secondary alcohols in the presence of primary ones has been achieved by the following sequences, (1) selective protection of primary alcohols with t-BuMe2SiCl, (2) oxidation of secondary alcohols with title reagents, and (3) deprotection of primary hydroxyls.

  在伯醇存在下仲醇的选择性氧化已通过以下顺序实现，(1) 用 t-BuMe2SiCl 选择性保护伯醇，(2) 用标题试剂氧化仲醇，以及 (3) 伯醇的脱保护羟基。