(E)-1-(4-丁氧基苯基)-3-苯基-丙-2-烯-1-酮 | 6307-05-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 中文名称: (E)-1-(4-丁氧基苯基)-3-苯基-丙-2-烯-1-酮
• 英文名称: (E)-1-(4-butoxyphenyl)-3-phenylprop-2-en-1-one
• 英文别名: 4'-butyloxy-trans-chalcone；4'-Butyloxy-trans-chalkon
• CAS: 6307-05-7；64990-87-0
• 化学式: C₁₉H₂₀O₂
• 分子量: 280.367
• InChiKey: NZTFLOLPHTVOCO-NTEUORMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-1-(4-丁氧基苯基)-3-苯基-丙-2-烯-1-酮 在 四氯化碳 、 溴 作用下， 生成 (2RS:3SR)-2,3-dibromo-3-phenyl-1-(4-butoxy-phenyl)-propanone-(1)
  参考文献：
  名称：

  ANTIMALARIALS. α,β-DIMORPHOLINYL KETONES AND RELATED COMPOUNDS^{1, 2}

  摘要：

  DOI：

  10.1021/jo01158a007
• 作为产物：
  描述：

  苯甲醛 、 4-(正丁氧基)苯乙酮 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 生成 (E)-1-(4-丁氧基苯基)-3-苯基-丙-2-烯-1-酮
  参考文献：
  名称：

  NIR optical carbon dioxide sensors based on highly photostable dihydroxy-aza-BODIPY dyes

  摘要：

  基于新型自参考近红外比色二羟基-氮杂BODIPY染料的光学二氧化碳传感器被提出。它们具有可调节的动态范围和无与伦比的光稳定性。

  DOI：

  10.1039/c5tc00346f

文献信息

• A New and Direct Synthesis of Chalcones Via TFAA-H3PO4 Mediated C-C Bond Forming Reaction
  作者：Kavitha Kankanala、Lingam Venkata Reddy、Vangala Ranga Reddy、Khagga Mukkanti、Sarbani Pal

  DOI：10.2174/157017811794557750

  日期：2011.1.1

  A number of α,β-unsaturated carboxylic acids were reacted with electron rich arenes or heteroarene in the presence of trifluoroacetic anhydride (TFAA) and H3PO4 at room temperature to give a variety of chalcone derivatives in good to excellent yields. The methodology was used to prepare novel compounds of potential pharmacological significances.

  多种α,β-不饱和羧酸与富电子的芳烃或杂芳烃在三氟乙酸酐（TFAA）和磷酸（H3PO4）存在下，于室温反应，以良好至优秀的产率合成了多种查耳酮衍生物。该方法学被用于制备具有潜在药理学意义的创新化合物。
• Ferrocenyl chalcones versus organic chalcones: A comparative study of their nematocidal activity
  作者：Saeed Attar、Zachary O’Brien、Hasan Alhaddad、Melissa L. Golden、Alejandro Calderón-Urrea

  DOI：10.1016/j.bmc.2011.01.048

  日期：2011.3

  A series of 30 organic chlacones and 33 ferrocenyl (Fc) chalcones were synthesized and characterized by melting point, elemental analysis, spectroscopy (H-1 NMR and FTIR) and, in two cases, by X-ray crystallography. The biological activity of each compound (10(-4) M in DMSO) against the model nematode Caenorhabditis elegans was examined in terms of % mortality (percent nematodes that died) and % fecundity (percent nematodes that reproduced) and compared to that obtained for the control medium (1% DMSO) over a 14-day period. Detailed conformational analyses for two Fc-chalcones (studied also by X-ray crystallography) were performed via molecular modeling studies. In general, the organic chalcones were found to be less polar than their Fc analogs. Some structure-activity relationships (SARs) were determined: (a) The nematocidal activities of the organic chalcones in this series were found to be much greater than those of their ferrocenyl analogs. (b) The position of the carbonyl group played a central role in the biological activity of both classes of chalcones studied. (c) For both classes of chalcones, lipophilicity of a compound seemed to play a significant role in its nematocidal activity. (d) The planarity of a ferrocenyl-chlacone seems to play a role in its activity. Published by Elsevier Ltd.
• TISHCHENKO I. G.; MALASHKO P. M.; MARKOVSKAYA V. S., VESTSI AN BSSR. CEP. XIM. N., IZV. AN BSSR. CEP. XIM. N., 1977, HO 4, 81-+
  作者：TISHCHENKO I. G.、 MALASHKO P. M.、 MARKOVSKAYA V. S.

  DOI：——

  日期：——