(4R,5R)-(2,2-dimethyl-5-propyl-1,3-dioxolan-4-yl)methanol | 160549-92-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4R,5R)-(2,2-dimethyl-5-propyl-1,3-dioxolan-4-yl)methanol
• 英文别名: (4R, 5R)-(2,2-Dimethyl-5-propyl-1,3-dioxolan-4-yl)methanol；[(4R,5R)-2,2-dimethyl-5-propyl-1,3-dioxolan-4-yl]methanol
• CAS: 160549-92-8
• 化学式: C₉H₁₈O₃
• 分子量: 174.24
• InChiKey: BIWWKAWWWUHFRE-HTQZYQBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4R,5R)-(2,2-dimethyl-5-propyl-1,3-dioxolan-4-yl)methanol 在 氢氧化钾 、 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 29.0h， 生成 (4R,5R)-2,2,5-trimethyl-4-propyl-1,3-dioxolane
  参考文献：
  名称：

  Schroeder, Frank; Fettkoether, Regina; Noldt, Uwe, Liebigs Annalen der Chemie, 1994, # 12, p. 1211 - 1218

  摘要：

  DOI：
• 作为产物：
  描述：

  (-)-2,3-O-亚异丙基-D-苏力糖醇 在 正丁基锂 、 copper(I) bromide dimethylsulfide complex 、 magnesium 作用下， 反应 4.42h， 生成 (4R,5R)-(2,2-dimethyl-5-propyl-1,3-dioxolan-4-yl)methanol
  参考文献：
  名称：

  Schroeder, Frank; Fettkoether, Regina; Noldt, Uwe, Liebigs Annalen der Chemie, 1994, # 12, p. 1211 - 1218

  摘要：

  DOI：

文献信息

• Mixtures and compositions suitable for controlling Hylotrupes bajulus and Pyrrhidium sanguineum
  申请人：BASF Aktiengesellschaft

  公开号：US06245328B1

  公开（公告）日：2001-06-12

  A mixture containing one stereoisomer of 3-hydroxyhexan-2-one and two stereoisomers of hexane-2,3-diol, especially (3R)-3-hydroxy-hexan-2-one, (2R,3R)-hexane-2,3-diol and/or (2R,3R)-hexane-2,3-diol and compositions containing them and the use of the mixture and of the compositions for controlling Hylotrupes bajulus and Pyrrhidium sanguineum by means of the monitoring, capture or mating disruption method are described.

  本文描述了一种混合物，其中包含3-羟基己酮的一个立体异构体和两个己二醇的立体异构体，特别是(3R)-3-羟基-己酮，(2R,3R)-己二醇和/或(2R,3R)-己二醇以及含有它们的组合物，并且利用该混合物和组合物通过监测、捕获或交配干扰方法控制松墨天牛和红天牛的使用。
• Divergent synthesis of (6S,1′S,2′R)-hydroxypestalotin via tandem conjugate addition–lactonization sequence
  作者：Venkata Satyanarayana Mallula、Batthula Srinivas、Palakodety Radha Krishna

  DOI：10.1016/j.tetlet.2015.01.069

  日期：2015.2

  The stereoselective synthesis of (65,1'S,2'R)-hydroxypestalotin from trans-hex-2-en-1-ol utilizing asymmetric dihydroxylation and Luche's reduction and tandem conjugative addition-lactonization as the key steps is reported. (C) 2015 Elsevier Ltd. All rights reserved.
• US6245328B1
  申请人：——

  公开号：US6245328B1

  公开（公告）日：2001-06-12
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：BARRY CLIFTON

  公开号：WO2011087995A2

  公开（公告）日：2011-07-21

  This invention provides compounds which are useful in the treatment of mycobacterial infections, pharmaceutical compositions containing the compounds, processes for their preparation, and uses of the compounds in various medicinal applications, such as the treatment or prevention of mycobacterial infections, such as those caused by Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium leprae, Mycobacterium africanum, Mycobacterium avium, Mycobacterium microti, or any mycobacterium that causes multi-drug resistant (MDR) TB or extensively resistant (XDR) TB, or any other mycobacterial species known to cause disease in humans; or the treatment or prevention of parasitic diseases, such as those caused by a parasite of the genus Trypanosoma, e.g. Trypanosoma cruzi or Trypanosoma brucei or a parasite of the genus Leishmania which causes visceral leishmaniasis or kala-azar, e.g., Leishmania donovani.