3-amino-2,4,6-trimethylbiphneyl | 131456-77-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-2,4,6-trimethylbiphneyl
• 英文别名: 2,4,6-trimethylbiphenyl-3-amine；2,4,6-Trimethyl-3-phenylaniline
• CAS: 131456-77-4
• 化学式: C₁₅H₁₇N
• 分子量: 211.307
• InChiKey: WBNZEKUSFJUAJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-amino-2,4,6-trimethylbiphneyl 在 盐酸 、 potassium iodide 、 sodium nitrite 作用下， 以 水 、 丙酮 为溶剂， 反应 2.0h， 以15%的产率得到3-iod-2,4,6-trimethylbiphenyl
  参考文献：
  名称：

  Fischer, Erika; Hess, Heinrich; Lorenz, Thomas, Chemische Berichte, 1991, vol. 124, # 4, p. 783 - 789

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4,6-三甲基联苯 在 palladium on activated charcoal 氢气 、 硝酸 、 乙酸酐 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 反应 48.67h， 生成 3-amino-2,4,6-trimethylbiphneyl
  参考文献：
  名称：

  Fischer, Erika; Hess, Heinrich; Lorenz, Thomas, Chemische Berichte, 1991, vol. 124, # 4, p. 783 - 789

  摘要：

  DOI：

文献信息

• Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
  申请人：Wu Chengde

  公开号：US20050049286A1

  公开（公告）日：2005-03-03

  The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

  这项发明涉及尿泉素II受体拮抗剂、CCR-9拮抗剂、含有它们的药物组合物以及它们的用途。
• Synthesis of biphenylamines via Suzuki–Miyaura cross-coupling reactions
  作者：Anna M. Maj、Lionel Delaude、Albert Demonceau、Alfred F. Noels

  DOI：10.1016/j.tet.2007.01.023

  日期：2007.3

  synthesized via Suzuki–Miyaura cross-coupling between bromoanilines and arylboronic acids using palladium catalysts. The experimental conditions were carefully adjusted to accommodate a wide range of substituents, in terms of electron-withdrawing or -donating ability and steric bulk. In some cases, protection and deprotection of the amine function via its trifluoroacetamide were added to the reaction sequence

  的一小库的元-和对位-biphenylamines取代的各种烷基，烷氧基，苯氧基，或卤代基在其芳环是经由使用钯催化剂和溴苯胺芳基硼酸之间的Suzuki-Miyaura交叉偶联合成。就吸电子或给电子能力和空间体积而言，仔细调整实验条件以适应广泛的取代基。在某些情况下，通过其三氟乙酰胺对胺官能团的保护和脱保护被添加到反应序列中，以促进交叉偶联步骤。
• Synthesis of N-heterocyclic carbene precursors bearing biphenyl units and their use in ruthenium-catalyzed ring-opening metathesis polymerization
  作者：Anna M. Maj、Lionel Delaude、Albert Demonceau、Alfred F. Noels

  DOI：10.1016/j.jorganchem.2007.03.027

  日期：2007.6

  A range of new imidazolium and imidazolinium chlorides bearing biphenyl units on their nitrogen atoms was synthesized. They differed by the electron-withdrawing or -donating nature and the steric bulk of the substituents on their aromatic rings. These various N-heterocyclic carbene (NHC) precursors were combined with the [RuCl2(p-cymene)](2) dimer and potassium tert-butoxide to generate the corresponding ruthenium-arene complexes [RuCl2(p-cymene)(NHC)] in situ. The catalytic activity of these species was investigated in the photoinduced ring-opening metathesis polymerization (ROMP) of cyclooctene. The results obtained confirmed the necessity of blocking the ortho-positions of the phenyl rings in the vicinity of the metal center in order to attain high catalytic efficiencies. They also showed that changing the steric and electronic properties of the substituents on the remote phenyl rings of the biphenyl units had no significant influence on the outcome of the polymerization. (C) 2007 Elsevier B.V. All rights reserved.
• FISCHER, E.;HESS, H.;LORENZ, TH., CHEM. BER., 124,(1991) N, C. 783-789
  作者：FISCHER, E.、HESS, H.、LORENZ, TH.

  DOI：——

  日期：——
• US7288538B2
  申请人：——

  公开号：US7288538B2

  公开（公告）日：2007-10-30