tert-butyl [5-(benzyloxy)-4-(di-tert-butylaminodicarbonate)-1,2-dihydro-1-(3,4-dihydroxybutyl)-2-oxopyrimido[4,5-d]pyrimidin-7-yl]-N-(methyl)carbamate | 1268383-27-2

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: tert-butyl [5-(benzyloxy)-4-(di-tert-butylaminodicarbonate)-1,2-dihydro-1-(3,4-dihydroxybutyl)-2-oxopyrimido[4,5-d]pyrimidin-7-yl]-N-(methyl)carbamate
• CAS: 1268383-27-2
• 化学式: C₃₃H₄₆N₆O₁₀
• 分子量: 686.762
• InChiKey: BJEYUPKJMOACMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.56
• 重原子数：
  49.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  195.74
• 氢给体数：
  2.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  tert-butyl [5-(benzyloxy)-4-(di-tert-butylaminodicarbonate)-1,2-dihydro-1-(3,4-dihydroxybutyl)-2-oxopyrimido[4,5-d]pyrimidin-7-yl]-N-(methyl)carbamate 在 sodium periodate 作用下， 以 二氯甲烷 、 水 、 1,2-二氯乙烷 为溶剂， 反应 24.0h， 生成 tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate
  参考文献：
  名称：

  Synthesis of a β-glycoside functionalized GΛC motif for self-assembly into rosette nanotubes with predefined length

  摘要：

  Progress toward the synthesis of guanine cytosine (G Lambda C) oligonucleotides for the spontaneous self-assembly of rosette nanotubes (RNTs) with predefined length is described. Highlighted is the synthesis of the beta-glycoside functionalized G Lambda C base along with a new nitrogen protecting group strategy that is compatible with Boc and Bn groups. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.122
• 作为产物：
  描述：

  tert-butyl [5-(benzyloxy)-1-(but-3-enyl)-4-(di-tert-butylaminodicarbonate)-1,2-dihydro-2-oxopyrimido[4,5-d]pyrimidin-7-yl]-N-(methyl)carbamate 在 四氧化锇 、 N-甲基吗啉氧化物 作用下， 以 水 、 丙酮 、 叔丁醇 为溶剂， 以77%的产率得到tert-butyl [5-(benzyloxy)-4-(di-tert-butylaminodicarbonate)-1,2-dihydro-1-(3,4-dihydroxybutyl)-2-oxopyrimido[4,5-d]pyrimidin-7-yl]-N-(methyl)carbamate
  参考文献：
  名称：

  Synthesis of a β-glycoside functionalized GΛC motif for self-assembly into rosette nanotubes with predefined length

  摘要：

  Progress toward the synthesis of guanine cytosine (G Lambda C) oligonucleotides for the spontaneous self-assembly of rosette nanotubes (RNTs) with predefined length is described. Highlighted is the synthesis of the beta-glycoside functionalized G Lambda C base along with a new nitrogen protecting group strategy that is compatible with Boc and Bn groups. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.122