(R)-1-methoxy-5-hexen-2-ol | 394657-89-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-1-methoxy-5-hexen-2-ol
• 英文别名: (2R)-1-methoxyhex-5-en-2-ol
• CAS: 394657-89-7
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: WZEGCVFTCLQLCX-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-1-methoxy-5-hexen-2-ol 在 Grubbs catalyst first generation 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 (Z)-(7R,14S)-7-Hexyl-14-methoxymethyl-7,8,9,12,13,14-hexahydro-6,15-dioxa-benzocyclotetradecene-5,16-dione
  参考文献：
  名称：

  Efficient phthalate-tethered ring-closing metathesis as a cross-coupling reaction

  摘要：

  An efficient method for cross-coupling using phthalate-tethered ring-closing metathesis was developed. Based on this method. the stereocontrolled syntheses of both (R,R)- and (S,R)-1-methoxypentadecane-2,9-diol (17, 20) were achieved from (R)-1-undecen-5-ol (4e) and (R)-1-methoxy-5-hexen-2-ol (13). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01649-5
• 作为产物：
  描述：

  (R)-(-)-环氧丙基甲基醚 、 alkaline earth salt of/the/ methylsulfuric acid 在 copper(l) iodide 作用下， 生成 (R)-1-methoxy-5-hexen-2-ol
  参考文献：
  名称：

  Efficient phthalate-tethered ring-closing metathesis as a cross-coupling reaction

  摘要：

  An efficient method for cross-coupling using phthalate-tethered ring-closing metathesis was developed. Based on this method. the stereocontrolled syntheses of both (R,R)- and (S,R)-1-methoxypentadecane-2,9-diol (17, 20) were achieved from (R)-1-undecen-5-ol (4e) and (R)-1-methoxy-5-hexen-2-ol (13). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01649-5

文献信息

• Efficient phthalate-tethered ring-closing metathesis as a cross-coupling reaction
  作者：Yasuharu Sakamoto、Masato Okazaki、Kazuyuki Miyamoto、Tadashi Nakata

  DOI：10.1016/s0040-4039(01)01649-5

  日期：2001.10

  An efficient method for cross-coupling using phthalate-tethered ring-closing metathesis was developed. Based on this method. the stereocontrolled syntheses of both (R,R)- and (S,R)-1-methoxypentadecane-2,9-diol (17, 20) were achieved from (R)-1-undecen-5-ol (4e) and (R)-1-methoxy-5-hexen-2-ol (13). (C) 2001 Elsevier Science Ltd. All rights reserved.