N,N′-((3S,7S,11S)-11-(2,3-bis(benzyloxy)-5-((E)-prop-1-en-1-yl)benzamido)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7-diyl)bis(2,3-bis(benzyloxy)benzamide) | 1407510-68-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N′-((3S,7S,11S)-11-(2,3-bis(benzyloxy)-5-((E)-prop-1-en-1-yl)benzamido)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7-diyl)bis(2,3-bis(benzyloxy)benzamide)
• 英文别名: N,N'-((3S,7S,11S)-11-(2,3-bis(benzyloxy)-5-((E)-prop-1-en-1-yl)benzamido)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7-diyl)bis(2,3-bis(benzyloxy)benzamide)；N-[(3S,7S,11S)-7,11-bis[[2,3-bis(phenylmethoxy)benzoyl]amino]-2,6,10-trioxo-1,5,9-trioxacyclododec-3-yl]-2,3-bis(phenylmethoxy)-5-[(E)-prop-1-enyl]benzamide
• CAS: 1407510-68-2
• 化学式: C₇₅H₆₇N₃O₁₅
• 分子量: 1250.37
• InChiKey: ZTVNZAUJMGJSFL-XCFUEJSISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.6
• 重原子数：
  93
• 可旋转键数：
  25
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  222
• 氢给体数：
  3
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  N,N′-((3S,7S,11S)-11-(2,3-bis(benzyloxy)-5-((E)-prop-1-en-1-yl)benzamido)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7-diyl)bis(2,3-bis(benzyloxy)benzamide) 在 sodium periodate 、 四氧化锇 作用下， 以 1,4-二氧六环 、 水 、 叔丁醇 为溶剂， 反应 2.5h， 以58%的产率得到N,N′-((3S,7S,11S)-11-(2,3-bis(benzyloxy)-5-formylbenzamido)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7-diyl)bis(2,3-bis(benzyloxy)benzamide)
  参考文献：
  名称：

  ENTEROBACTIN CONJUGATES AND USES THEREOF

  摘要：

  本发明提供了新型肠杆菌铁胞内载体共轭物，如式(I)化合物及其盐，其中X是载体，可以是抗生素、荧光素或生物素。本发明还提供了涉及式(I)化合物的络合物、组合物、试剂盒和方法，用于将载体传递给细菌，治疗受试者的细菌感染、囊性纤维化和/或炎症性肠病，预防受试者的细菌感染、囊性纤维化和/或炎症性肠病，抑制或杀死细菌的生长，或确定生物样品中细菌的浓度。在某些实施例中，细菌是革兰氏阴性细菌。

  公开号：

  US20150105337A1
• 作为产物：
  描述：

  (E)-2,3-bis(benzyloxy)-5-(prop-1-en-1-yl)benzoic acid 、 2,3-双(苄氧基)苯甲酸 、 (3S,7S,11S)-3,7,11-triamino-1,5,9-trioxacyclodecane-2,6,10-trione 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 以37%的产率得到N,N′-((3S,7S,11S)-11-(2,3-bis(benzyloxy)-5-((E)-prop-1-en-1-yl)benzamido)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7-diyl)bis(2,3-bis(benzyloxy)benzamide)
  参考文献：
  名称：

  Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Scaffolds and Evaluation of Enterobactin–Cargo Conjugate Uptake

  摘要：

  The design and syntheses of monofunctionalized enterobactin (Ent, L- and D-isomers) scaffolds where one catecholate moiety of enterobactin houses an alkene, aldehyde, or carboxylic acid at the C5 position are described. These molecules are key precursors to a family of 10 enterobactin-cargo conjugates presented in this work, which were designed to probe the extent to which the Gram-negative ferric enterobactin uptake and processing machinery recognizes, transports, and utilizes derivatized enterobactin scaffolds. A series of growth recovery assays employing enterobactin-deficient E. coli ATCC 33475 (ent-) revealed that six conjugates based on L-Ent having relatively small cargos promoted E. coli growth under iron limiting conditions whereas negligible-to-no growth recovery was observed for four conjugates with relatively large cargos. No growth recovery was observed for the enterobactin receptor deficient strain of E. coli H1187 (fepA-) or the enterobactin esterase deficient derivative of E. coli K-12 JW0576 (fes-), or when the D-isomer of enterobactin was employed These results demonstrate that the E. coli ferric enterobactin transport machinery identifies and delivers select cargo-modified scaffolds to the E. coli cytoplasm. Pseudomonas aeruginosa PAO1 K648 (pvd-, pch-) exhibited greater promiscuity than that of E. coli for the uptake and utilization of the enterobactin-cargo conjugates, and growth promotion was observed for eight conjugates under iron-limiting conditions. Enterobactin may be utilized for delivering molecular cargos via its transport machinery to the cytoplasm of E. coli and P. aeruginosa thereby providing a means to overcome the Gram-negative outer membrane permeability barrier.

  DOI：

  10.1021/ja3077268

文献信息

• US9902986B2
  申请人：——

  公开号：US9902986B2

  公开（公告）日：2018-02-27