(RS)-{2-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-4-phenylethynyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-phenyl}-carbamic acid tert-butyl ester | 335351-58-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (RS)-{2-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-4-phenylethynyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-phenyl}-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[2-[[3-(3-imidazol-1-ylphenyl)-3-oxopropanoyl]amino]-5-[2-(oxan-2-yloxy)ethoxy]-4-(2-phenylethynyl)phenyl]carbamate
• CAS: 335351-58-1
• 化学式: C₃₈H₄₀N₄O₇
• 分子量: 664.758
• InChiKey: KDEHYSDCHCKIAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  49
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one 、 (RS)-{2-Amino-4-phenylethynyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-phenyl }-carbamic acid tert-butyl ester 生成 (RS)-{2-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-4-phenylethynyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-phenyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Glutamate receptor antagonists

  摘要：

  这项发明涉及具有公式1的基本结构的化合物。 公式I的化合物被证明具有作为代谢型谷氨酸受体拮抗剂的活性。

  公开号：

  US06407094B1

文献信息

• [EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1<br/>[FR] INHIBITEURS DE 11-BETA-HYDROXY-STEROIDE-DESHYDROGENASE DE TYPE 1
  申请人：BIOVITRUM AB

  公开号：WO2001090090A1

  公开（公告）日：2001-11-29

  The present invention relates to compounds with the formula (II) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of thecompounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

  本发明涉及式（II）的化合物，以及包含该化合物的药物组合物，以及其制备过程，以及化合物在医学上的应用以及用于制备对人类11-β-羟基类固醇脱氢酶1型酶有作用的药物。
• BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1224174A2

  公开（公告）日：2002-07-24
• INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
  申请人：BIOVITRUM AB

  公开号：EP1283831A1

  公开（公告）日：2003-02-19
• US6407094B1
  申请人：——

  公开号：US6407094B1

  公开（公告）日：2002-06-18
• [EN] BENZODIAZEPINE DERIVATIVES<br/>[FR] DERIVES DE BENZODIAZEPINES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2001029011A2

  公开（公告）日：2001-04-26

  The present invention relates to compounds of general formula (I) wherein X is a single bond or an ethynediyl group, wherein, in case X is a single bond, R1 is halogen or phenyl which is optionally substituted with halogen, lower alkyl, halo-lower alkyl, lower alkoxy, halo-lower alkoxy, or cyano; In case X is an ethynediyl group, R1 is phenyl, optionally substituted with halogen, lower alkyl, halo-lower alkyl, lower cycloalkyl, lower alkoxy or halo-lower alkoxy; R3 is a 5 or 6 membered aryl or heteroaryl which are optionally substituted. The compounds according to the present invention can be used for treating or preventing acute and/or chronic neurological disorders such as psychosis, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits.