5α-stigmastan-6-one | 101064-58-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5α-stigmastan-6-one
• 英文别名: 6-kitositostanol；5α-stigmastanone-(6)；5α-Stigmastanon-(6)；5alpha-Stigmastan-6-one；(5S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-one
• CAS: 101064-58-8
• 化学式: C₂₉H₅₀O
• 分子量: 414.715
• InChiKey: WSFPFPXLMYCOBT-PSTOXXEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5α-stigmastan-6-one 生成 6-hydroxyimino-5α-stigmastane
  参考文献：
  名称：

  Pragmatic guidelines for determining road investment priorities in developing countries

  摘要：

  In many developing countries, the determination of a ranking of investments designed to improve and extend the road system is a commonplace prerequisite of planning for the transport sector as a whole and the road sub-sector within it. A major objective of determining investment priorities is to secure the greatest efficiency in the use of resources allocated to the sector and, for this reason, any system of assigning priorities must rely upon conventional investment appraisal techniques producing quantifiable measures of worth. Exercises of this kind, in which road investments are identified and ranked, are usually undertaken to produce a road sector investment plan. The implementation of such plans is, however, often compromised because of perceived deficiencies with a methodology which places undue reliance on investment appraisal and fails to properly address the issue of public interest and sustainability. This paper attempts to produce a pragmatic set of ground rules which, while mindful of the need to promote economic efficiency, allow for other factors to be embraced in a more holistic methodology.

  DOI：

  10.1080/13504500209470118
• 作为产物：
  描述：

  stigmast-5-ene 在 硝酸 、 溶剂黄146 、 锌 作用下， 生成 5α-stigmastan-6-one
  参考文献：
  名称：

  Pragmatic guidelines for determining road investment priorities in developing countries

  摘要：

  In many developing countries, the determination of a ranking of investments designed to improve and extend the road system is a commonplace prerequisite of planning for the transport sector as a whole and the road sub-sector within it. A major objective of determining investment priorities is to secure the greatest efficiency in the use of resources allocated to the sector and, for this reason, any system of assigning priorities must rely upon conventional investment appraisal techniques producing quantifiable measures of worth. Exercises of this kind, in which road investments are identified and ranked, are usually undertaken to produce a road sector investment plan. The implementation of such plans is, however, often compromised because of perceived deficiencies with a methodology which places undue reliance on investment appraisal and fails to properly address the issue of public interest and sustainability. This paper attempts to produce a pragmatic set of ground rules which, while mindful of the need to promote economic efficiency, allow for other factors to be embraced in a more holistic methodology.

  DOI：

  10.1080/13504500209470118

文献信息

• Synthesis and biological activity of 6a-carbabrassinolide: B-ring homologation of 6-oxo-steroid to 6-oxo-7a-homosteroid with trimethylsilyldiazomethane-boron trifluoride etherate
  作者：Hideharu Seto、Shozo Fujioka、Hiroyuki Koshino、Hideki Hayasaka、Takeshi Shimizu、Shigeo Yoshida、Tsuyoshi Watanabe

  DOI：10.1016/s0040-4039(99)00186-0

  日期：1999.3

  From castasterone (10), 6a-carbabrassinolide (2) was synthesized via a highly regioselective B-ring homologation with trimethylsilyldiazomethane and boron trifluoride etherate. A preliminary experiment using a simple 6-oxo-steroid (3) revealed that the actual products of this homologation reaction were α-trimethylsilyl ketones (4) and (5), which were converted to 6 (79%) and 7 (7.2%) by acid treatment

  通过三区域甲硅烷基重氮甲烷和三氟化硼醚化物的高度区域选择性B环同系物，从蓖麻甾酮（10）合成了6a-氨基甲酸酯（2）。使用简单的6-氧-甾族化合物（3）进行的初步实验表明，该同源反应的实际产物是α-三甲基甲硅烷基酮（4）和（5），它们分别转化为6（79％）和7（7.2％） ）经酸处理。的生物活性2在水稻叶片倾斜测试是CA。相比1，这表明在该图6a-氧1 是这项活动的重要但非必要因素。
• Ahmad, M. S.; Ansari, Imtiaz A.; Ansari, Shamim A., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 664 - 666
  作者：Ahmad, M. S.、Ansari, Imtiaz A.、Ansari, Shamim A.、Moinuddin, G.

  DOI：——

  日期：——