Nonanoic acid 6-chloro-1H-indol-3-yl ester | 133950-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Nonanoic acid 6-chloro-1H-indol-3-yl ester
• 英文别名: 6-Chloro-3-indoxyl nonanoate；(6-chloro-1H-indol-3-yl) nonanoate
• CAS: 133950-72-8
• 化学式: C₁₇H₂₂ClNO₂
• 分子量: 307.82
• InChiKey: STALAAUKINVVQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  42.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  壬酰氯 、 1-乙酰基-6-氯-1H- 吲哚-3-乙酯 在 sodium hydroxide 作用下， 生成 Nonanoic acid 6-chloro-1H-indol-3-yl ester
  参考文献：
  名称：

  Synthèse de substrats indigogéniques. Mise en évidence de l'activité estérasique des Salmonella

  摘要：

  DOI：

  10.1016/0223-5234(90)90135-p

文献信息

• Method and medium for etecting/identifying micro-orgranisms with esterase activity
  申请人：——

  公开号：US20040048326A1

  公开（公告）日：2004-03-11

  The invention relates to a method and a medium for microbiological analysis by biochemical means involving chromogenic or fluorogenic substrates that react with enzymes (esterases) specific for the target strains. One object of the invention is to improve the sensitivity, initial translucence, stability and ease of use of such detection/identification media. For this purpose the medium according to the invention is characterized in that it is in a stable, ready-to-use liquid or gel form and in that it contains a solubilizer and stabilizer selected from fatty acid sorbitan esters, bile salts and mixtures thereof, as well as a selective activator selected from alkylsulfate salts, for example the sodium salts. The medium can comprise a solvent, for example dimethyl sulfoxide. The invention further relates to the method of obtaining this medium and to the use of products of the sodium alkylsulfate type as selective activators in such media.

  本发明涉及一种通过生化手段进行微生物分析的方法和培养基，该方法和培养基涉及与目标菌株特异性酶（酯酶）反应的致色或致氟底物。 本发明的一个目的是提高这种检测/鉴定培养基的灵敏度、初始半透明性、稳定性和易用性。为此目的，根据本发明的培养基的特点是：它是稳定的、即用型液体或凝胶状，含有选自脂肪酸山梨醇酯、胆汁盐及其混合物的增溶剂和稳定剂，以及选自烷基硫酸盐（例如钠盐）的选择性活化剂。介质可以包括溶剂，例如二甲亚砜。 本发明还涉及获得这种培养基的方法，以及在这种培养基中使用烷基硫酸钠类产品作为选择性活化剂。
• AGBAN, A.;OUNANIAN, M.;LUU-DUC, C.;MONGET, D., EUR. J. MED. CHEM., 25,(1990) N, C. 697-699
  作者：AGBAN, A.、OUNANIAN, M.、LUU-DUC, C.、MONGET, D.

  DOI：——

  日期：——
• PROCEDE ET MILIEU DE DETECTION/IDENTIFICATION DE MICROORGANISMES A ACTIVITE ESTERASIQUE
  申请人：BIO MERIEUX

  公开号：EP1334204B1

  公开（公告）日：2007-10-31
• Method and medium for the detecting/identifying microorganisms with esterase and/or r osidase and/or peptidase and/or sulfatase and/or phosphatase activity
  申请人：Gilbert Sandra

  公开号：US20050014215A1

  公开（公告）日：2005-01-20

  The invention relates to a medium for biological analysis by biochemical means involving chromogenic or fluorogenic substrates that react with enzymes (esterases and/or osidases and/or peptidases and/or sulfatases and/or phosphatases) specific for the target strains. The object of the invention is to improve the sensitivity, initial translucence, stability and ease of use of such identification/detection media. This object is achieved by the medium according to the invention, which is in a stable, ready-to-use liquid or gel form and contains at least one emulsifying stabilizer of the fatty acid sorbitan ester/fatty acid type and at least one solvent (dimethyl sulfoxide). This medium is obtained by mixing a stock solution of esterase and/or osidase and/or peptidase and/or sulfatase and/or phosphatase substrates in the solvent, and the emulsifying stabilizer, with some of the constituents of the culture medium. The invention further relates to the preparation of such a medium and to the use of a fatty acid sorbitan ester/fatty acids as an emulsifying stabilizer in a medium for the detection/identification of microorganisms, especially bacteria or yeasts, with esterase and/or osidase and/or peptidase and/or sulfatase and/or phosphatase activities.
• US7217536B2
  申请人：——

  公开号：US7217536B2

  公开（公告）日：2007-05-15