Cis,exo-perhydroindole-2-L-carboxylic acid hydrochloride | 110623-68-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cis,exo-perhydroindole-2-L-carboxylic acid hydrochloride
• 英文别名: octahydroindole-2-carboxylic acid hydrochloride；octahydro-1H-indol-2-carboxylic acid hydrochloride；2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carboxylic acid hydrochloride；2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carboxylic acid;hydrochloride
• CAS: 110623-68-2
• 化学式: C₉H₁₅NO₂*ClH
• 分子量: 205.685
• InChiKey: PONAUWFRJYNGAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.41
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  49.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Cis,exo-perhydroindole-2-L-carboxylic acid hydrochloride 生成 Cis,exo-N-benzoyl-perhydroindole-2-L-carboxylic acid
  参考文献：
  名称：

  ROOS, OTTO;LOSEL, WALTER;SCHNORRENBERG, GERD;GAIDA, WOLFRAM;HOEFKE, WOLFG+

  摘要：

  DOI：
• 作为产物：
  描述：

  3,3a,4,5,6,7-2H-hexahydroindole-2-carboxylic acid hydrochloride 在 铂 氢气 作用下， 以 溶剂黄146 为溶剂， 生成 Cis,exo-perhydroindole-2-L-carboxylic acid hydrochloride
  参考文献：
  名称：

  WO2006/137082

  摘要：

  公开号：

文献信息

• [EN] [B]-FUSED BICYCLIC PROLINE DERIVATIVES AND THEIR USE FOR TREATING ARTHRITIC CONDITIONS<br/>[FR] DERIVES BICYCLIQUES [B]-FUSIONNES DE PROLINE ET LEUR UTILISATION POUR TRAITER DES ETATS ARTHRITIQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2004092132A1

  公开（公告）日：2004-10-28

  The invention relates to a compound which is [b]-fused bicyclic proline derivative, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the compound or the salt thereof, and methods of treating diseases, including, but not limited to, methods of preventing or inhibiting joint cartilage damage and preventing or treating diseases characterized by joint cartilage damage, joint inflammation, or joint pain. The [b]-fused bicyclic proline derivatives are compounds of Formula I as described above. Diseases characterized by joint cartilage damage or joint pain include, for example, osteoarthritis and rheumatoid arthritis. Rheumatoid arthritis is also characterized by joint inflammation. This invention also relates to methods of synthesizing and preparing the [b]-fused bicyclic proline derivatives, or a pharmaceutically acceptable salt thereof.

  该发明涉及一种[b]-融合双环脯氨酸衍生物，或其药用盐；包括该化合物或其盐的药物组合物；以及治疗疾病的方法，包括但不限于预防或抑制关节软骨损伤，预防或治疗以关节软骨损伤、关节炎或关节疼痛为特征的疾病的方法。[b]-融合双环脯氨酸衍生物是上述化合物的I式化合物。以关节软骨损伤或关节疼痛为特征的疾病包括骨关节炎和类风湿性关节炎。类风湿性关节炎也以关节炎为特征。该发明还涉及合成和制备[b]-融合双环脯氨酸衍生物或其药用盐的方法。
• [EN] PROCESSES FOR THE SYNTHESIS OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIC ACID AS AN INTERMEDIATE FOR TRANDOLAPRIL<br/>[FR] PROCÉDÉS DE SYNTHÈSE D'ACIDE (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIQUE COMME INTERMÉDIAIRE POUR LE TRANDOLAPRIL
  申请人：ABBOTT LAB

  公开号：WO2011009021A1

  公开（公告）日：2011-01-20

  Processes for the preparation of (2S, 3aR, 7aS) -octahydro-1H-indole-20carboxylic acid hydrochloride starting from (1S, 2S) -2- [ (S) -1- phenylethyl amino] cyclohexyl) methanol are described.

  描述了从（1S, 2S）-2-[(S)-1-苯乙基氨基]环己基）甲醇出发制备（2S, 3aR, 7aS）-辛氢-1H-吲哚-2-羧酸盐酸盐的过程。
• Process for the preparation of perindopril and salts thereof
  申请人：Sochinaz SA

  公开号：EP1864973A1

  公开（公告）日：2007-12-12

  The present invention describes a novel method for the synthesis of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid, or of one of its aryl esters of formula XIII wherein X and Y are a hydrogen atom, a halogen, alkyl, alkoxyl or nitro group, and the conversion of the paranitrobenzyl ester of formula X into Perindopril of formula I or one of its salts.

  本发明描述了一种新的方法，用于合成(2S,3aS,7aS)-八氢吲哚-2-羧酸或其式XIII的芳基酯之一，其中X和Y是氢原子、卤素、烷基、烷氧基或硝基基团，并将式X的对硝基苄酯转化为公益普利或其盐之一的式I。
• Process for making perhydroindole-2-carbonxylic acid
  申请人：Roussel Uclaf

  公开号：US04879392A1

  公开（公告）日：1989-11-07

  A process for the asymmetric preparation of a compound of the formula ##STR1## wherein the hydrogen at 3a and 7a are of cis or trans configuration and their non-toxic, pharmaceutically acceptable acid addition salts comprising submitting a compound of the formula ##STR2## to a Hoffman reaction and reacting the resulting product with formaldehyde in the presence of cyanide ions and acid halide of benzoic acid or an aliphatic carboxylic acid of 1 to 5 carbon atoms to obtain a compound of the formula ##STR3## wherein R is acyl of benzoic acid or aliphatic carboxylic acid of 1 to 5 carbon atoms, cyclizing the latter to form a compound of the formula ##STR4## selectively hydrolyzing the latter with a dilute aqueous mineral acid to obtain a compound of the formula ##STR5## subjecting the latter to hydrolysis with a concentrated aqueous mineral acid to form the acid addition salt of a compound of claim 1 and optionally forming the free base.

  一种用于不对称制备式为## STR1 ##的化合物的过程，其中3a和7a处的氢原子为顺式或反式构型，其非毒性、药学上可接受的酸盐包括将式为## STR2 ##的化合物提交给霍夫曼反应，并在氰离子和苯甲酸或1至5个碳原子的脂肪族羧酸的酸卤的存在下，将所得产物与甲醛反应，得到式为## STR3 ##的化合物，其中R为苯甲酰基或1至5个碳原子的脂肪族羧酸基，将后者环化形成式为## STR4 ##的化合物，用稀释的水矿酸选择性水解后者，得到式为## STR5 ##的化合物，将后者经浓烈的水矿酸水解，形成权利要求1中化合物的酸盐，并可选择形成游离碱。
• PROCESS FOR THE SYNTHESIS OF (2S,3AR,7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIC ACID AS AN INTERMEDIATE FOR TRANDOLAPRIL
  申请人：Chemburkar Sanjay R.

  公开号：US20110065930A1

  公开（公告）日：2011-03-17

  A process for the preparation of (2S,3aR,7aS)-octahydro-1H-indole-20carboxylic acid hydrochloride.

  一种制备（2S，3aR，7aS）-八氢-1H-吲哚-2-0-羧酸盐酸盐的方法。