(-)-Cannabisativine | 135266-71-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: (-)-Cannabisativine
• 英文别名: Cannabisativine；(13S,17S)-17-[(1S,2R)-1,2-dihydroxyheptyl]-1,5,10-triazabicyclo[11.4.0]heptadec-15-en-11-one
• CAS: 135266-71-6
• 化学式: C₂₁H₃₉N₃O₃
• 分子量: 381.559
• InChiKey: KZZKPJBKEJKNAK-HUUJSLGLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  84.8
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine 在 甲醇 、 4-二甲氨基吡啶 、 barium dihydroxide 、 lithium aluminium tetrahydride 、 萘 、 2-氯-1-甲基吡啶碘化物 、 sodium 、 potassium carbonate 、 对甲苯磺酸 、 丙酮 、 肼 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 甲苯 、 苯 为溶剂， 反应 20.0h， 生成 (-)-Cannabisativine
  参考文献：
  名称：

  （-）-大麻二酚的手性合成：高度非对映选择性杂Diels-Alder反应的应用

  摘要：

  合成多胺生物碱大麻脂为光学活性形式。关键步骤是手性二烯与N-甲苯磺胺的杂Diels-Alder反应，其中区域和非对映异构体的选择性得到完全控制，仅高产率地分离出一个非对映异构体。除了αD值外，合成的（-）-大麻二酚具有与天然产物相同的物理数据。

  DOI：

  10.1016/s0040-4039(00)74295-x

文献信息

• Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
  申请人：Ovokaitys Todd Frank

  公开号：US10384985B2

  公开（公告）日：2019-08-20

  The present specification describes increasing the Brix degree, nutrient transport and density, and yields of cannabis crops through the application of photoacoustic resonance to a nutrient formulation. An activated nutrient solution is obtained by forming an unactivated nutrient solution and applying to the unactivated nutrient solution ultra-rapid impulses of modulated laser light, from one or more laser systems. An increase of at least 5% in the Brix degree of the crop, relative to an unactivated nutrient formulation, can be achieved. In addition, an increase of at least 5%, relative to an unactivated nutrient formulation, is seen with respect to nutrient density and crop yield through application of the activated nutrient solution.

  本说明书描述了通过对营养液配方应用光声共振来提高 Brix 度、养分运输和密度 以及大麻作物的产量。通过形成未激活的营养液，并对未激活的营养液施加来自一个或多个激光系统的超快速脉冲调制激光，可获得活化营养液。与未激活的营养液相比，作物的白利糖度可提高至少 5%。此外，通过施用活化营养液，营养密度和作物产量也比未活化营养液至少提高 5%。
• Compound and method for treating spasms, inflammation and pain
  申请人：Kariman Alexander

  公开号：US10751380B2

  公开（公告）日：2020-08-25

  The disclosed invention generally relates to pharmaceutical and nutraceutical compounds and methods for reducing inflammation, muscle spasms, and pain associated with cancer, trauma, medical procedure, neurological diseases and disorders, as well as other conditions in subjects in need thereof. The disclosed invention further relates to Mitragyna speciose and Cannabis sativa based compounds and synthetic analogs of the alkaloids found in said plants, where said compounds can also contain a pharmacologically inactive substance for modifying certain qualities of said compounds.

  本发明一般涉及药物和营养保健品化合物及方法，用于减轻炎症、肌肉痉挛以及与癌症、创伤、医疗过程、神经系统疾病和失调有关的疼痛，以及有需要的受试者的其他病症。本发明还涉及到基于密蒙花（Mitragyna speciose）和大麻（Cannabis sativa）的化合物以及在上述植物中发现的生物碱的合成类似物，其中所述化合物还可以含有一种药理上无活性的物质，用于改变所述化合物的某些性质。
• TOPICAL REGIONAL NEURO-AFFECTIVE THERAPY WITH CARYOPHYLLENE
  申请人：Afgin Pharma, Llc

  公开号：EP3500235A1

  公开（公告）日：2019-06-26
• METHODS AND COMPOSITIONS FOR ENHANCING HEALTH
  申请人：Ojai Energetics PBC

  公开号：EP3600271A1

  公开（公告）日：2020-02-05
• Methods and Compositions for Increasing the Yield of, and Beneficial Chemical Composition of, Certain Plants
  申请人：Ovokaitys Todd Frank

  公开号：US20180127327A1

  公开（公告）日：2018-05-10

  The present specification describes increasing the Brix degree, nutrient transport and density, and yields of cannabis crops through the application of photoacoustic resonance to a nutrient formulation. An activated nutrient solution is obtained by forming an unactivated nutrient solution and applying to the unactivated nutrient solution ultra-rapid impulses of modulated laser light, from one or more laser systems. An increase of at least 5% in the Brix degree of the crop, relative to an unactivated nutrient formulation, can be achieved. In addition, an increase of at least 5%, relative to an unactivated nutrient formulation, is seen with respect to nutrient density and crop yield through application of the activated nutrient solution.