2-Methyl-3-(2-methyl-1,3-oxazol-4-yl)prop-2-enal | 139630-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Methyl-3-(2-methyl-1,3-oxazol-4-yl)prop-2-enal
• CAS: 139630-91-4
• 化学式: C₈H₉NO₂
• 分子量: 151.165
• InChiKey: REKPDRFUTJJZPF-UHFFFAOYSA-N

物化性质

• 沸点：
  263.4±15.0 °C(Predicted)
• 密度：
  1.108±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  2-Methyl-3-(2-methyl-1,3-oxazol-4-yl)prop-2-enal 、 丙酸(1S,2R)-2-[N-苄基-N-(均三甲苯基磺酰)氨基]-1-苯基丙酯 在 三乙胺 、 双环己基(三氟甲烷磺酰氧基)硼烷 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 、
  参考文献：
  名称：

  Synthetic studies on the phorboxazoles: a short synthesis of an epi-C23 tetrahydropyran core

  摘要：

  Studies on the synthesis of the anticancer natural products, the phorboxazoles, have led to the synthesis of the C21-C32 penta-substituted tetrahydropyran core which is epimeric to the natural product at C23. The synthesis was achieved in only seven linear steps. The key steps were the use of a Masamune-Abiko anti-aldol reaction, the formation of a dihydropyran precursor molecule by the use of a new 'Maitland-Japp-like' cyclisation, and a highly diastereoselective reductive alkylation of the dihydropyran double bond, to generate the corresponding tetrahydropyran ring in an excellent yield. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.012

文献信息

• METHOD FOR PRODUCING OLEFIN COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1970368A1

  公开（公告）日：2008-09-17

  A method for producing an olefin compound represented by the formula (2): wherein R1 and R2 are the same or different, and independently represent an alkyl group or the like, with the proviso that R1 and R2 are not hydrogen atoms at the same time, R3 represents an alkyl group or the like, which comprises contacting a palladium catalyst with an α,β-unsaturated aldehyde compound represented by the formula (1): wherein R1, R2 and R3 are the same as defined above, in the presence of an inorganic base.

  一种生产由式（2）表示的烯烃化合物的方法： 其中 R1 和 R2 相同或不同，并独立地代表烷基或类似物，但 R1 和 R2 不能同时为氢原子，R3 代表烷基或类似物，该方法包括将钯催化剂与α，β-不饱和醛化合物接触，该醛化合物由式（1）表示： 其中 R1、R2 和 R3 与上述定义相同，在无机碱存在下。
• US7985872B2
  申请人：——

  公开号：US7985872B2

  公开（公告）日：2011-07-26
• Synthetic studies on the phorboxazoles: a short synthesis of an epi-C23 tetrahydropyran core
  作者：Paul A. Clarke、Jason M. Hargreaves、Daniel J. Woollaston、Rosa María Rodríguez Sarmiento

  DOI：10.1016/j.tetlet.2010.07.012

  日期：2010.9

  Studies on the synthesis of the anticancer natural products, the phorboxazoles, have led to the synthesis of the C21-C32 penta-substituted tetrahydropyran core which is epimeric to the natural product at C23. The synthesis was achieved in only seven linear steps. The key steps were the use of a Masamune-Abiko anti-aldol reaction, the formation of a dihydropyran precursor molecule by the use of a new 'Maitland-Japp-like' cyclisation, and a highly diastereoselective reductive alkylation of the dihydropyran double bond, to generate the corresponding tetrahydropyran ring in an excellent yield. (C) 2010 Elsevier Ltd. All rights reserved.