1-Cyclohexyl-3-[4-(7-methyl-3-phenyl-4,5,6,7-tetrahydroindazol-2-yl)phenyl]sulfonylurea | 1427056-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Cyclohexyl-3-[4-(7-methyl-3-phenyl-4,5,6,7-tetrahydroindazol-2-yl)phenyl]sulfonylurea
• 英文别名: 1-cyclohexyl-3-[4-(7-methyl-3-phenyl-4,5,6,7-tetrahydroindazol-2-yl)phenyl]sulfonylurea
• CAS: 1427056-09-4
• 化学式: C₂₇H₃₂N₄O₃S
• 分子量: 492.642
• InChiKey: BEJYRAICEQEZNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-2-亚苄基-6-甲基环己酮 在 溴 、 potassium carbonate 作用下， 以 乙醇 、 水 、 丙酮 为溶剂， 反应 25.5h， 生成 1-Cyclohexyl-3-[4-(7-methyl-3-phenyl-4,5,6,7-tetrahydroindazol-2-yl)phenyl]sulfonylurea
  参考文献：
  名称：

  Synthesis and in vitro antitumor and antimicrobial activity of some 2,3-diaryl-7-methyl-4,5,6,7-tetrahydroindazole and 3,3a,4,5,6,7-hexahydroindazole derivatives

  摘要：

  The synthesis of a series of 2,3-diaryl-7-methyl-4,5,6,7-tetrahydroindazole and 3,3a, 4,5,6,7-hexahydroindazole derivatives substituted with various biologically-active function groups with anticipated chemotherapeutic activity is described. 4-(7-methyl-3-aryl-3,3a, 4,5,6,7-hexahydro-indazol-2-yl)benzenesulfonamides 2a-c, which were employed as key intermediates in this study, were synthesized by cyclocondensation of 6-arylidene-2-methylcyclohexanones 1a-c with 4-hydrazinobenzenesulfonamide hydrochloride. A detailed discussion of the reactions utilized in the preparation of the intermediate and target compounds is reported, and the structures of the newly synthesized compounds were substantiated with IR, H-1 and C-13 NMR spectral data and elementary microanalyses. Twenty of the newly synthesized compounds were selected by National Cancer Institute (NCI), Maryland, USA, to be evaluated for their antitumor activity and the results revealed that six compounds 3c, 4d, e, 5a, d and 8c exhibited broad spectrum of antitumor activity against most of the tested tumor cell lines. In addition, the in vitro antibacterial and antifungal activities of a number of the target compounds were also tested using the Agar-diffusion method. Some of these compounds have shown significant antibacterial and mild to moderate antifungal activities.

  DOI：

  10.3109/14756366.2011.653354

文献信息

• Synthesis and <i>in vitro</i> antitumor and antimicrobial activity of some 2,3-diaryl-7-methyl-4,5,6,7-tetrahydroindazole and 3,3a,4,5,6,7-hexahydroindazole derivatives
  作者：Hassan M. Faidallah、Khalid A. Khan、Sherif A. F. Rostom、Abdullah M. Asiri

  DOI：10.3109/14756366.2011.653354

  日期：2013.6.1

  The synthesis of a series of 2,3-diaryl-7-methyl-4,5,6,7-tetrahydroindazole and 3,3a, 4,5,6,7-hexahydroindazole derivatives substituted with various biologically-active function groups with anticipated chemotherapeutic activity is described. 4-(7-methyl-3-aryl-3,3a, 4,5,6,7-hexahydro-indazol-2-yl)benzenesulfonamides 2a-c, which were employed as key intermediates in this study, were synthesized by cyclocondensation of 6-arylidene-2-methylcyclohexanones 1a-c with 4-hydrazinobenzenesulfonamide hydrochloride. A detailed discussion of the reactions utilized in the preparation of the intermediate and target compounds is reported, and the structures of the newly synthesized compounds were substantiated with IR, H-1 and C-13 NMR spectral data and elementary microanalyses. Twenty of the newly synthesized compounds were selected by National Cancer Institute (NCI), Maryland, USA, to be evaluated for their antitumor activity and the results revealed that six compounds 3c, 4d, e, 5a, d and 8c exhibited broad spectrum of antitumor activity against most of the tested tumor cell lines. In addition, the in vitro antibacterial and antifungal activities of a number of the target compounds were also tested using the Agar-diffusion method. Some of these compounds have shown significant antibacterial and mild to moderate antifungal activities.