2-phenyl-5-phenylmethoxy-1,3-dioxane | 41128-90-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenyl-5-phenylmethoxy-1,3-dioxane
• 英文别名: cis-5-(benzyloxy)-2-phenyl-1,3-dioxane
• CAS: 41128-90-9
• 化学式: C₁₇H₁₈O₃
• 分子量: 270.328
• InChiKey: LYULANJSVNVULZ-CALCHBBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-phenyl-5-phenylmethoxy-1,3-dioxane 在 吡啶 、 钯 、 溶剂黄146 作用下， 生成 Glycerin-1,3-dibenzoat
  参考文献：
  名称：

  Some New Glycerol Derivatives

  摘要：

  DOI：

  10.1021/ja01133a535
• 作为产物：
  描述：

  trans-2-Phenyl-1,3-dioxan-5-ol 生成 2-phenyl-5-phenylmethoxy-1,3-dioxane
  参考文献：
  名称：

  甘油酯合成物：II. 由 2-O-苄基甘油制备对称饱和单酸甘油二酯

  摘要：

  描述了对称饱和单酸甘油二酯的直接制备。合成包括 2-O-苄基甘油的制备、乙酰化、与硬脂酸甲酯或棕榈酸甲酯的酯交换以及氢解以产生所需的 1,3-甘油二酯。对称甘油二酯的熔点略高于之前通过其他合成方法获得的熔点，这些方法涉及酰基的 1,2 至 1,3 位移。

  DOI：

  10.1139/v55-156

文献信息

• Simultaneous Interaction with Base and Phosphate Moieties Modulates the Phosphodiester Cleavage of Dinucleoside 3‘,5‘-Monophosphates by Dinuclear Zn²⁺ Complexes of Di(azacrown) Ligands
  作者：Qi Wang、Harri Lönnberg

  DOI：10.1021/ja058806s

  日期：2006.8.1

  ability of the Zn(2+) complexes of these ligands to promote the transesterification of dinucleoside 3',5'-monophosphates to a 2',3'-cyclic phosphate derived from the 3'-linked nucleoside by release of the 5'-linked nucleoside has been studied over a narrow pH range, from pH 5.8 to 7.2, at 90 degrees C. The dinuclear complexes show marked base moiety selectivity. Among the four dinucleotide 3',5'-phosphates

  已经合成了五个双核配体 (1-5) 和一个三核配体 (6)，其中包含连接到芳族支架上的 1,5,9-triazacyclododecan-3-yloxy 基团。这些配体的 Zn(2+) 复合物促进双核苷 3',5'-单磷酸酯转酯化为 2',3'-环状磷酸酯的能力，该磷酸酯衍生自 3'-连接的核苷，释放 5'已在 90 摄氏度的狭窄 pH 范围（从 pH 5.8 到 7.2）研究了-连接的核苷。双核复合物显示出显着的碱基部分选择性。在研究的四种二核苷酸 3',5'-磷酸中，即。adenylyl-3',5'-adenosine (ApA), adenylyl-3',5'-uridine (ApU), uridylyl-3',5'-adenosine (UpA), and uridylyl-3',5'-uridine (上U), 含有一个尿嘧啶碱基 (ApU 和 UpA) 的二聚体比含有两个尿嘧啶碱基
• Glycerol conversion to high-value chemicals: the implication of unnatural α-amino acid syntheses using natural resources
  作者：Yun Ji Park、Jung Woon Yang

  DOI：10.1039/c9gc00755e

  日期：——

  oxidised to produce a high-value compound in high yield using a NaOtBu-O2 system. Furthermore, the synthetic utility of the resulting product was demonstrated by its transformation into unnatural α-amino acids, thus showing the valorisation of glycerol biomass.

  甘油衍生物是一类重要的化合物，作为有机合成中的基本结构基石具有很大的应用前景。使用NaO t Bu-O 2系统将O-苄基甘油氧化以高收率生产高价值的化合物。此外，通过将其转化为非天然的α-氨基酸证明了所得产物的合成效用，从而表明了甘油生物质的增值。
• Binding of Tetramethylammonium to Polyether Side-Chained Aromatic Hosts. Evaluation of the Binding Contribution from Ether Oxygen Donors
  作者：Sandra Bartoli、Gina De Nicola、Stefano Roelens

  DOI：10.1021/jo034905h

  日期：2003.10.1

  A set of macrocyclic and open-chain aromatic ligands endowed with polyether side chains has been prepared to assess the contribution of ether oxygen donors to the binding of tetramethylammonium (TMA), a cation believed incapable of interacting with oxygen donors. The open-chain hosts consisted of an aromatic binding site and side chains possessing a variable number of ether oxygen donors; the macrocyclic ligands were based on the structure of a previously investigated host, the dimeric cyclophane 1,4-xylylene-1,4-phenylene diacetate (DXPDA), implemented with polyether-type side chains in the backbone. Association to tetramethylammonium picrate (TMAP) was measured in CDCl3 at T = 296 K by H-1 NMR titrations. Results confirm that the main contribution to the binding of TMA comes from the cation-pi interaction established with the aromatic binding sites, but they unequivocally show that polyether chains participate with cooperative contributions, although of markedly smaller entity. Water is also bound, but the two guests interact with aromatic rings and oxygen donors in an essentially noncompetitive way. An improved procedure for the preparation of cyclophanic tetraester derivatives has been developed that conveniently recycles the oligomeric ester byproducts formed in the one-pot cyclization reaction. An alternative entry to benzylic diketones has also been provided that makes use of a low-order cyanocuprate reagent to prepare in fair yields a class of compounds otherwise uneasily accessible.
• Schmidt; Blank, Chemische Berichte, 1956, vol. 89, p. 283,287
  作者：Schmidt、Blank

  DOI：——

  日期：——
• Baggett et al., Journal of the Chemical Society, 1960, p. 2574
  作者：Baggett et al.

  DOI：——

  日期：——