N-(tert-butyl)prop-2-ene-1-sulfonamide | 1443452-34-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N-(tert-butyl)prop-2-ene-1-sulfonamide
• 英文别名: N-tert-butylprop-2-ene-1-sulfonamide
• CAS: 1443452-34-3
• 化学式: C₇H₁₅NO₂S
• 分子量: 177.268
• InChiKey: ZYXFCHHVTRGOAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(tert-butyl)prop-2-ene-1-sulfonamide 、 异戊醛 在 三甲基溴硅烷 作用下， 以 neat (no solvent) 为溶剂， 反应 18.0h， 以71%的产率得到rac-(3R,5S)-5-bromo-3-isobutyl-1,2-thiazinane 1,1-dioxide
  参考文献：
  名称：

  Solvent-Free, Metal-Free, Aza-Prins Cyclization: Unprecedented Access to δ-Sultams

  摘要：

  Aza-Prins and the pauper: Aza-Prins cyclization between γ,δ-unsaturated tosylamines and aldehydes was successfully performed under solvent-free and metal-free conditions. When applied to β,γ-unsaturated sulfonamides, the corresponding δ-sultams were isolated in good yields (see scheme). This approach constitutes a new route to cyclic sulfonamides.

  DOI：

  10.1002/chem.201203415
• 作为产物：
  描述：

  2-丙烯-1-磺酰氯 、 叔丁胺 以 乙腈 为溶剂， 生成 N-(tert-butyl)prop-2-ene-1-sulfonamide
  参考文献：
  名称：

  Solvent-Free, Metal-Free, Aza-Prins Cyclization: Unprecedented Access to δ-Sultams

  摘要：

  Aza-Prins and the pauper: Aza-Prins cyclization between γ,δ-unsaturated tosylamines and aldehydes was successfully performed under solvent-free and metal-free conditions. When applied to β,γ-unsaturated sulfonamides, the corresponding δ-sultams were isolated in good yields (see scheme). This approach constitutes a new route to cyclic sulfonamides.

  DOI：

  10.1002/chem.201203415

文献信息

• Solvent-Free, Metal-Free, Aza-Prins Cyclization: Unprecedented Access to δ-Sultams
  作者：Damien Clarisse、Béatrice Pelotier、Fabienne Fache

  DOI：10.1002/chem.201203415

  日期：2013.1.14

  Aza-Prins and the pauper: Aza-Prins cyclization between γ,δ-unsaturated tosylamines and aldehydes was successfully performed under solvent-free and metal-free conditions. When applied to β,γ-unsaturated sulfonamides, the corresponding δ-sultams were isolated in good yields (see scheme). This approach constitutes a new route to cyclic sulfonamides.