10-n-butyl-2-hydroxyacridin-9(10H)-one | 1609179-50-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-n-butyl-2-hydroxyacridin-9(10H)-one
• 英文别名: 10-Butyl-2-hydroxyacridin-9-one；10-butyl-2-hydroxyacridin-9-one
• CAS: 1609179-50-1
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: YGKFTBOKSCTMKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  10-丁基-2-氯-9(10H)-吖啶酮 在 2-二叔丁基膦-2′,4′,6′-三异丙基-3,6-二甲氧基-1,1′-联苯 、 C₄₄H₆₂NO₅PPdS 、 水 、 potassium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 18.0h， 以98%的产率得到10-n-butyl-2-hydroxyacridin-9(10H)-one
  参考文献：
  名称：

  Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst

  摘要：

  A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (1,5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.

  DOI：

  10.1021/jo500662s

文献信息

• Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
  作者：Chi Wai Cheung、Stephen L. Buchwald

  DOI：10.1021/jo500662s

  日期：2014.6.6

  A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (1,5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.