lauric acid-(4-hydroxy-butyl ester) | 34511-40-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: lauric acid-(4-hydroxy-butyl ester)
• 英文别名: Laurinsaeure-(4-hydroxy-butylester)；4-Hydroxybutyl dodecanoate
• CAS: 34511-40-5
• 化学式: C₁₆H₃₂O₃
• 分子量: 272.428
• InChiKey: VWMDGDKJQSDMSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  19
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  lauric acid-(4-hydroxy-butyl ester) 、 氯磷酸二乙酯 在 吡啶 、 乙醚 作用下， 生成 phosphoric acid diethyl ester-(4-lauroyloxy-butyl ester)
  参考文献：
  名称：

  Swern et al., Journal of Chemical and Engineering Data, 1958, vol. 3, p. 346,347

  摘要：

  DOI：
• 作为产物：
  描述：

  月桂酸 、 1,4-丁二醇 在 硫酸 、 甲苯 作用下， 生成 lauric acid-(4-hydroxy-butyl ester)
  参考文献：
  名称：

  Swern et al., Journal of Chemical and Engineering Data, 1958, vol. 3, p. 346,347

  摘要：

  DOI：

文献信息

• UV ABSORBER FORMULATIONS
  申请人：Acker Stephanie

  公开号：US20100111884A1

  公开（公告）日：2010-05-06

  Disclosed is a UV filter composition comprising (a) an organic UV absorber of formula (1), wherein R 1 and R 2 , independently of one another, are C 3 -C 18 alkyl; C 2 -C 18 alkenyl; a radical of the formula —CH 2 —CH(OH)—CH 2 —O-T 1 ; or R 1 and R 2 are a radical of the formula (4a); R 7 is a direct bond; a straight-chain or branched C 1 -C 4 alkylene radical or a radical of the formula (I) or (II); R 8 , R 9 and R 10 , independently of one another, are C 1 -C 18 alkyl; C 1 -C 18 alkoxy or a radical of the formula (III); R 11 is C 1 -C 5 alkyl; m 1 is a number from 1 to 4; p 1 is 0; or a number from 1 to 5; A 1 is a radical of the formula (1b), (1c) or (1d); R 3 is hydrogen; C 1 -C 10 alkyl; —(CH 2 CHR 5 —O)n 1 -T 2 ; or —CH 2 —CH(—OH)—CH 2 —O-T 2 ; R 4 is hydrogen; M; C 1 -C 5 alkyl; or —(CH 2 )m 2 —O-T 3 ; R 5 is hydrogen; or methyl; T 1 , T 2 and T 3 independently from each other are hydrogen; or C 1 -C 18 alkyl; Q 1 is C 1 -C 18 alkyl, M is a metal cation; m 2 is 1 to 4; and n 1 is 1-16, (b) dimethyl capramide, (c) a cosmetically acceptable carrier; and water.

  本发明公开了一种紫外线过滤组合物，包括（a）式（1）的有机紫外线吸收剂，其中R1和R2独立地是C3-C18烷基；C2-C18烯基；式—CH2—CH（OH）—CH2—O-T1的基团；或者R1和R2是式（4a）的基团；R7是直链或支链C1-C4烷基、式（I）或（II）的基团；R8、R9和R10独立地是C1-C18烷基、C1-C18烷氧基或式（III）的基团；R11是C1-C5烷基；m1是1至4的数字；p1是0或1至5的数字；A1是式（1b）、（1c）或（1d）的基团；R3是氢、C1-C10烷基、式—（CH2CHR5—O）n1-T2或式—CH2—CH（—OH）—CH2—O-T2；R4是氢、M、C1-C5烷基或式—（CH2）m2—O-T3；R5是氢或甲基；T1、T2和T3互相独立地是氢或C1-C18烷基；Q1是C1-C18烷基，M是金属阳离子；m2是1至4的数字；n1是1-16，（b）二甲基辛酰胺，（c）化妆品可接受载体；和水。
• Diffusion matrix for transdermal drug administration and transdermal drug delivery devices including same
  申请人：CYGNUS THERAPEUTIC SYSTEMS

  公开号：EP0272918A2

  公开（公告）日：1988-06-29

  A solid state, resilient laminated composite for administering a drug transdermally consisting of a top layer of a resilient elastomer; a middle diffusion matrix layer composed of a polyurethane macroporous foam framework in whose pores are embedded a viscoelastic blend of a medical grade polysiloxane adhesive, drug, and optionally a percutaneous absorption enhancer, and a basal surface layer of the medical grade polysiloxane adhesive.

  一种用于经皮给药的固态弹性层压复合材料，由弹性人造橡胶表层、由聚氨酯大孔泡沫框架组成的中间扩散基质层（其孔隙中嵌入了医用级聚硅氧烷粘合剂、药物和经皮吸收促进剂的粘弹性混合物）以及医用级聚硅氧烷粘合剂基底表层组成。
• Solid drug-delivery devices employing fatty acid esters or fatty alcohol ethers of alkanediols as percutaneous absorption enhancers
  申请人：CYGNUS THERAPEUTIC SYSTEMS

  公开号：EP0483105A1

  公开（公告）日：1992-04-29

  A solid state, resilient laminated composite for administering estradiol transdermally consisting of a multiplicity of spaced structural laminas of a resilient elastomer, one of which forms the top of the composite, a viscoelastic hydrophobic polymer lamina containing propylene glycol monolaurate interposed between each structural lamina and a pressure-sensitive adhesive lamina that provides the basal surface of the composite and consists of a blend of a pressure-sensitive adhesive, estradiol, and propylene glycol monolaurate.

  一种用于经皮给药雌二醇的固态弹性层状复合材料，由多个间隔排列的弹性弹性体结构层组成，其中一个结构层构成复合材料的顶部，每个结构层之间有一个含有单月桂酸丙二醇酯的粘弹性疏水聚合物层，以及一个提供复合材料基面的压敏粘合层，该粘合层由压敏粘合剂、雌二醇和单月桂酸丙二醇酯混合组成。
• THICKENING COMPOSITION
  申请人：Ajinomoto Co., Inc.

  公开号：EP1746141A1

  公开（公告）日：2007-01-24

  The present invention provides a thickening composition simultaneously exhibiting suitable thickening performance and superior usability, which contains N-long-chain acyl acidic amino acid and/or a salt thereof, an amphipathic substance, an inorganic salt, and water as essential components, and has a viscosity of not less than 200 mPa·s. By the addition of the thickening composition, moreover, cleansing compositions and cosmetic compositions for skin, hair and the like, which maintain thickening performance and usability, while containing N-long-chain acyl acidic amino acid and/or a salt thereof are provided.

  本发明提供了一种增稠组合物，它同时具有合适的增稠性能和优异的使用性，其主要成分包括 N-长链酰基酸性氨基酸和/或其盐、两性物质、无机盐和水，粘度不低于 200 mPa-s。此外，通过添加该增稠组合物，还可提供用于皮肤、头发等的清洁组合物和化妆品组合物，这些组合物在保持增稠性能和可用性的同时，还含有 N-长链酰基酸性氨基酸和/或其盐。
• THICKENER/GELLANT FOR OILY SUBSTANCE
  申请人：Mizutani, Genzo

  公开号：EP2208769A1

  公开（公告）日：2010-07-21

  The purpose of the invention is to provide a thickening and gelling agent that is easily dispersed into an oily substance such as a silicone oil in a small addition amount, is free of liquid separation, stably forms a thickened material or a gel state, and can prepare a thickened product or a gel having spreadability and free of sticky feeling and dry feeling. The invention provides a thickening and gelling agent for an oily substance containing the components (A) a modified product of alkoxytitanium or alkoxyzirconium with a carboxylic acid and a hydroxy compound, and (B) at least one silicone oil selected from a silicone oil having an amino group and a silicone oil having a carboxyl group; an oily composition and a cosmetic preparation, containing the thickening and gelling agent.

  本发明的目的是提供一种增稠剂和胶凝剂，该增稠剂和胶凝剂易于以较小的添加量分散到硅油等油性物质中，无液体分离，能稳定地形成增稠物质或凝胶状态，并能制备出具有铺展性、无粘稠感和干燥感的增稠产品或凝胶。本发明提供了一种油性物质的增稠剂和胶凝剂，其成分包括：（A）烷氧基钛或烷氧基锆与羧酸和羟基化合物的改性产物；（B）至少一种硅油，选自具有氨基的硅油和具有羧基的硅油；含有该增稠剂和胶凝剂的油性组合物和化妆品制剂。