(8-chloro-octyl)-methyl sulfide | 98956-33-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (8-chloro-octyl)-methyl sulfide
• 英文别名: 1-Chlor-8-methylmercapto-octan；(8-Chlor-octyl)-methyl-sulfid；1-Chloro-8-methylsulfanyloctane
• CAS: 98956-33-3
• 化学式: C₉H₁₉ClS
• 分子量: 194.769
• InChiKey: GJNBNDTWFDOTNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (8-chloro-octyl)-methyl sulfide 在 乙醇 、 氯仿 、 碳酸氢钠 、 一水合肼 、 N,N-二甲基甲酰胺 作用下， 生成 8-(甲硫基)辛基异硫氰酸酯
  参考文献：
  名称：

  Kjaer; Christensen, Acta Chemica Scandinavica (1947), 1957, vol. 11, p. 1298,1300,1305

  摘要：

  DOI：
• 作为产物：
  描述：

  8-氯-1-辛醇 在 氯化亚砜 、 乙醇 作用下， 生成 (8-chloro-octyl)-methyl sulfide
  参考文献：
  名称：

  Familial Head and Neck Cancer: Molecular Analysis of a New Clinical Entity

  摘要：

  AbstractObjective The tumor suppressor gene p16 encodes a cyclin‐dependent kinase inhibitor that normally inhibits cell proliferation by causing a G1 cell cycle arrest. The p16 gene is frequently mutated in a variety of somatic tumors, as well as in familial melanoma and familial pancreatic carcinoma. We identified a family with a high incidence of head and neck squamous cell carcinoma (HNSCC) and melanoma. Molecular analyses of the p16 gene locus in blood and tumor DNA from this family was performed to determine whether an association between germline p16 gene mutation and HNSCC exists.Study Design Molecular pedigree analyses.Methods Exon 2 of p16 was polymerase chain reaction amplified from blood, tumor, or nontumor DNA isolated from affected and unaffected members, then directly sequenced and compared with consensus p16 sequence. Cell cycle position of cells expressing wild‐type or mutant p16 was determined by flow cytometry.Results Molecular analyses revealed a nonfunctional germline point mutation within exon 2 of the p16 gene that encodes a mutant p16 protein substituting proline at amino acid position 87 for the wild‐type arginine (p16R87P). Relative to wild‐type p16, p16R87P lost ability to cause a growth arrest following ectopic expression. The mutant (p16R87P) allele segregated with cancer predisposition in tested family members, and analyses of HNSCC tumor tissues demonstrated universal loss of wild‐type allele.Conclusions Significance of the mutant p16 (p16R87P) in HNSCC tumorigenesis is strongly suggested by its loss of cell cycle arrest activity and its retention in tumor tissue with simultaneous loss of the wild‐type allele. Further, the germline p16 mutation segregated with cancer predisposition within the family. In aggregate, these data suggest that there is a direct causal relationship between the germline p16 mutation in this family and HNSCC tumorigenesis. Based on our observations, the spectrum of familial cancers associated with p16 mutations should include a new clinical entity, familial HNSCC.

  DOI：

  10.1097/00005537-200209000-00010

文献信息

• Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions
  申请人：——

  公开号：US20020010082A1

  公开（公告）日：2002-01-24

  Compositions including one or more anionic polymerization initiators and one or more additives for improving functionalizing efficiency of living polymer anions are disclosed. The present invention also provides compositions including one or more electrophiles and one or more additives for improving functionalizing efficiency of living polymer anions. Novel electrophiles and processes for improving polymer anion functionalization efficiencies are also disclosed.

  本发明公开了包括一种或多种阴离子聚合引发剂和一种或多种添加剂的组合物，用于提高活聚合物阴离子的官能化效率。本发明还提供了包括一种或多种亲电体和一种或多种添加剂的组合物，用于提高活聚合物阴离子的官能化效率。本发明还公开了用于提高聚合物阴离子官能化效率的新型亲电剂和工艺。
• COMPOSITIONS PROVIDING IMPROVED FUNCTIONALIZATION OF TERMINAL ANIONS AND PROCESSES FOR IMPROVED FUNCTIONALIZATION OF TERMINAL ANIONS
  申请人：FMC CORPORATION

  公开号：EP1028982A1

  公开（公告）日：2000-08-23
• US6545103B2
  申请人：——

  公开号：US6545103B2

  公开（公告）日：2003-04-08
• US6605564B1
  申请人：——

  公开号：US6605564B1

  公开（公告）日：2003-08-12
• US6858679B2
  申请人：——

  公开号：US6858679B2

  公开（公告）日：2005-02-22