8-methylthio-1-octanol | 98957-86-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 8-methylthio-1-octanol
• 英文别名: 8-methylsulfanyl-1-octanol；8-(methylthio)octan-1-ol；8-methylsulfanyl-octan-1-ol；8-Methylmercapto-octan-1-ol；8-Methylsulfanyl-1-octanol；8-methylsulfanyloctan-1-ol
• CAS: 98957-86-9
• 化学式: C₉H₂₀OS
• 分子量: 176.323
• InChiKey: AGDCIOVLTTWMHF-UHFFFAOYSA-N

物化性质

• 熔点：
  12 °C
• 沸点：
  135-138 °C(Press: 10 Torr)
• 密度：
  0.935±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-methylthio-1-octanol 在 一水合肼 、 N,N'-二环己基碳二亚胺 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 为溶剂， 生成 8-(甲硫基)辛基异硫氰酸酯
  参考文献：
  名称：

  Kawabata, Jun; Fukushi, Yukiharu; Hayashi, Ryoko, Agricultural and Biological Chemistry, 1989, vol. 53, # 12, p. 3361 - 3362

  摘要：

  DOI：
• 作为产物：
  描述：

  1,8-辛二醇 在 氢溴酸 作用下， 以 甲醇 为溶剂， 生成 8-methylthio-1-octanol
  参考文献：
  名称：

  Kawabata, Jun; Fukushi, Yukiharu; Hayashi, Ryoko, Agricultural and Biological Chemistry, 1989, vol. 53, # 12, p. 3361 - 3362

  摘要：

  DOI：

文献信息

• Compounds and methods for repelling blood-feeding arthropods and deterring their landing and feeding
  申请人：Gries Regine M.

  公开号：US09789044B2

  公开（公告）日：2017-10-17

  This invention relates to a group of compounds for repelling blood-feeding ectoparasitic arthropods, and a method of deterring their landing and feeding on animals including humans, by applying in one or more formulations compounds that incorporate one or more sulfide and one or more hydroxyl groups to the skin, clothing or environment of animals, including humans. A method of repelling and deterring landing and feeding by blood-feeding arthropods on an animal by applying in effective amount one or more compounds that incorporate alkyl sulfide and alcohol moieties, or alkyl sulfide and amide moieties, or alkyl sulfide and amide moieties to the skin, clothing or environment of an animal.

  这项发明涉及一组化合物，用于驱赶吸血外寄生节肢动物，并通过在动物（包括人类）的皮肤、衣物或环境中应用包含一种或多种硫化物和一种或多种羟基基团的化合物的一个或多个配方来阻止它们着陆和吸食。一种通过在动物的皮肤、衣物或环境中应用包含烷基硫化物和醇基团、或烷基硫化物和酰胺基团、或烷基硫化物和酰胺基团的一种或多种化合物的有效量来驱赶和阻止吸血节肢动物在动物身上着陆和吸食的方法。
• COMPOUNDS AND METHODS FOR REPELLING BLOOD-FEEDING ARTHROPODS AND DETERRING THEIR LANDING AND FEEDING
  申请人：Gries Regine M

  公开号：US20110251270A1

  公开（公告）日：2011-10-13

  This invention relates to a group of compounds for repelling blood-feeding ectoparasitic arthropods, and a method of deterring their landing and feeding on animals including humans, by applying in one or more formulations compounds that incorporate one or more sulfide and one or more hydroxyl groups to the skin, clothing or environment of animals, including humans. A method of repelling and deterring landing and feeding by blood-feeding arthropods on an animal by applying in effective amount one or more compounds that incorporate alkyl sulfide and alcohol moieties, or alkyl sulfide and amide moieties, or alkyl sulfide and amide moieties to the skin, clothing or environment of an animal.

  本发明涉及一类化合物，用于驱避吸血性外寄生节肢动物，并通过将含有一种或多种硫化物和一种或多种羟基的化合物应用于动物（包括人类）的皮肤、衣服或环境中的一种或多种制剂来防止它们降落和吸血。本发明还涉及一种通过在动物的皮肤、衣服或环境中应用一种或多种含有烷基硫醇和醇基或烷基硫醇和酰胺基或烷基硫醇和酰胺基的化合物的有效量来驱避和防止血吸虫降落和吸血的方法。
• 화합물 또는 그 염, 지질 입자 및 의약 조성물
  申请人：후지필름 가부시키가이샤

  公开号：KR20230162043A

  公开（公告）日：2023-11-28

  본 발명은, 높은 핵산 내포율 및 우수한 핵산 송달을 실현할 수 있는 지질 입자를 구성하는 화합물 또는 그 염, 및 이것을 이용한, 높은 핵산 내포율 및 우수한 핵산 송달을 실현할 수 있는 지질 입자 및 의약 조성물을 제공하는 것을 과제로 한다. 본 발명에 의하면, 하기 식 (1)로 나타나는 화합물 또는 그 염이 제공된다. 식 중, 각 기호는, 본 명세서에 정의한 의미를 나타낸다.

  本发明的目的是提供由能够高核酸掺入和优异核酸递送的脂质颗粒组成的化合物或其盐，以及能够高核酸掺入和优异核酸递送的脂质颗粒和使用其的药物组合物。根据本发明，提供了由下式（1）表示的化合物或其盐。式中，各符号具有本文所定义的含义。
• Familial Head and Neck Cancer: Molecular Analysis of a New Clinical Entity
  作者：Kathy K. Yu、Adam M. Zanation、Jonathan R. Moss、Wendell G. Yarbrough

  DOI：10.1097/00005537-200209000-00010

  日期：2002.9

  AbstractObjective The tumor suppressor gene p16 encodes a cyclin‐dependent kinase inhibitor that normally inhibits cell proliferation by causing a G1 cell cycle arrest. The p16 gene is frequently mutated in a variety of somatic tumors, as well as in familial melanoma and familial pancreatic carcinoma. We identified a family with a high incidence of head and neck squamous cell carcinoma (HNSCC) and melanoma. Molecular analyses of the p16 gene locus in blood and tumor DNA from this family was performed to determine whether an association between germline p16 gene mutation and HNSCC exists.Study Design Molecular pedigree analyses.Methods Exon 2 of p16 was polymerase chain reaction amplified from blood, tumor, or nontumor DNA isolated from affected and unaffected members, then directly sequenced and compared with consensus p16 sequence. Cell cycle position of cells expressing wild‐type or mutant p16 was determined by flow cytometry.Results Molecular analyses revealed a nonfunctional germline point mutation within exon 2 of the p16 gene that encodes a mutant p16 protein substituting proline at amino acid position 87 for the wild‐type arginine (p16R87P). Relative to wild‐type p16, p16R87P lost ability to cause a growth arrest following ectopic expression. The mutant (p16R87P) allele segregated with cancer predisposition in tested family members, and analyses of HNSCC tumor tissues demonstrated universal loss of wild‐type allele.Conclusions Significance of the mutant p16 (p16R87P) in HNSCC tumorigenesis is strongly suggested by its loss of cell cycle arrest activity and its retention in tumor tissue with simultaneous loss of the wild‐type allele. Further, the germline p16 mutation segregated with cancer predisposition within the family. In aggregate, these data suggest that there is a direct causal relationship between the germline p16 mutation in this family and HNSCC tumorigenesis. Based on our observations, the spectrum of familial cancers associated with p16 mutations should include a new clinical entity, familial HNSCC.
• Kjaer; Christensen, Acta Chemica Scandinavica (1947), 1957, vol. 11, p. 1298,1300,1305
  作者：Kjaer、Christensen

  DOI：——

  日期：——