2,5-dimethyl-3-(2,4-dimethoxy-phenyl)-7-(diethylamino)pyrazolo[2,3-a]pyrimidine | 863550-35-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,5-dimethyl-3-(2,4-dimethoxy-phenyl)-7-(diethylamino)pyrazolo[2,3-a]pyrimidine
• 英文别名: 3-(2,4-dimethoxyphenyl)-N,N-diethyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine
• CAS: 863550-35-0
• 化学式: C₂₀H₂₆N₄O₂
• 分子量: 354.452
• InChiKey: PBFYJNMYFNPGNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二乙胺 、 2,5-dimethyl-3-(2,4-dimethoxyphenyl)-7-chloropyrazolo[1,5-a]pyrimidine 以 乙腈 为溶剂， 反应 0.27h， 生成 2,5-dimethyl-3-(2,4-dimethoxy-phenyl)-7-(diethylamino)pyrazolo[2,3-a]pyrimidine
  参考文献：
  名称：

  [EN] CRF RECEPTOR ANTAGONISTS, THEIR PREPARATIONS, THEIR PHARMACEUTICAL COMPOSITION AND THEIR USES
  [FR] ANTAGONISTES DU RECEPTEUR DE LA CORTICOLIBERINE, LEUR PREPARATION, LEUR COMPOSITION PHARMACEUTIQUE ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2005079868A3

文献信息

• CRF RECEPTOR ANTAGONISTS, THEIR PREPARATIONS, THEIR PHARMACEUTICAL COMPOSITION AND THEIR USES
  申请人：SB Pharmco Puerto Rico Inc.

  公开号：EP1722826A2

  公开（公告）日：2006-11-22
• Crf receptor antagonists, their preparations, their pharmaceutical composition, and their uses
  申请人：Grigoriadis Dimitri

  公开号：US20070129382A1

  公开（公告）日：2007-06-07

  CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in warm-blooded animals. CRF receptor antagonists which are labeled with a positron emitting isotope for use in PET are also disclosed.