cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid | 118514-35-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid
• CAS: 118514-35-5
• 化学式: C₁₂H₁₈O₆
• 分子量: 258.271
• InChiKey: AZWHPGZNOIYGFB-AQHSTMNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.44
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  111.9
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid 在 对甲苯磺酸 作用下， 以 xylene 为溶剂， 反应 12.0h， 以97%的产率得到(1R,5S,7s)-1,5,7-trimethyl-2,4-dioxo-3-oxabicyclo[3.3.1]nonane-7-carboxylic acid
  参考文献：
  名称：

  Molecular recognition with convergent functional groups. VI. Synthetic and structural studies with a model receptor for nucleic acid components

  摘要：

  DOI：

  10.1021/ja00185a044
• 作为产物：
  描述：

  TRIMETHYL CIS,CIS-1,3,5-CYCLOHEXANETRICARBOXYLATE 、 硫酸二甲酯 生成 KEMP'S TRIACID 、 cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid
  参考文献：
  名称：

  Molecular recognition with convergent functional groups. VI. Synthetic and structural studies with a model receptor for nucleic acid components

  摘要：

  DOI：

  10.1021/ja00185a044

文献信息

• CURING AGENTS FOR EPOXY RESINS
  申请人：Dershem Stephen M

  公开号：US20130012620A1

  公开（公告）日：2013-01-10

  The present invention relates to curatives for epoxy resins, and compositions (e.g. adhesives) containing such resins cured using the same methods of preparation and uses therefor. More specifically, the present invention relates to hybrid curatives for epoxy resins comprising both aromatic amine, phenol and/or phenyl ester moieties. A further aspect of the current invention relates to new imidazole catalysts that possess a combination of excellent cure latency as well as low cure temperature onset.

  本发明涉及环氧树脂的硬化剂，以及含有经相同制备方法固化的这种树脂的组合物（例如胶粘剂）及其用途。更具体地，本发明涉及用于环氧树脂的混合硬化剂，包括芳香胺、酚和/或苯酯基团。本发明的另一个方面涉及具有优异固化潜伏期和低固化温度起始点的新咪唑催化剂。
• New Kemp’s Diacid Derivatives Give Efficient Transport and Modifiable Selectivity for Alkaline Earth and Transition Metal Ions
  作者：Bruce W. Baldwin、Takuji Hirose、Zhen-He Wang、Tadafumi Uchimaru、Ari Yliniemelä

  DOI：10.1246/bcsj.70.1895

  日期：1997.8

  New derivatives of 1,3,5-trimethyl-r-1, c-3, c-5-cyclohexanetricarboxylic acid (Kemp’s triacid) showed high efficiency for alkaline earth and transition metal ion transport through a chloroform liquid membrane. Simple syntheses from Kemp’s triacid or its geometric isomer provided chelating agents with a tripodal binding site for metal cations. The tripodal binding site consisted of r-1, c-3-diaxial

  1,3,5-三甲基-r-1、c-3、c-5-环己烷三羧酸（肯普三酸）的新衍生物显示出通过氯仿液膜传输碱土金属和过渡金属离子的高效率。坎普三酸或其几何异构体的简单合成为螯合剂提供了金属阳离子的三足结合位点。三足结合位点由 r-1、c-3-双轴羧基和 c-5-酰胺、酯或 C-甲基组成。碱土金属运输变化很大，对 c-5 基团的变化很敏感。对于过渡金属运输，c-5-酰胺二酸具有较高的总运输效率。对于 c-5-酯或 C-甲基二酸，较小的二价阳离子的络合减少，导致对大阳离子的选择性增加。
• Improved microwave oven synthesis of amides and imides promoted by imidazole; convenient transport agent preparation
  作者：Bruce W. Baldwin、Takuji Hirose、Zhen-He Wang

  DOI：10.1039/cc9960002669

  日期：——

  Microwave dielectric loss heating without solvent or support yields amides and imides from aromatic and sterically hindered acids in the presence of imidazole in good to excellent yields under mild irradiation conditions.

  在温和的辐照条件下，无溶剂或支撑物的微波介质损耗加热可在咪唑存在下从芳香族和立体受阻酸中产生酰胺和亚胺，产率从良好到极佳。
• Synthesis and Evaluation of Superior Calcium and Mercury Transport by Simple Monocarboxylic Acids of Kemp’s Triacid
  作者：Takuji Hirose、Zhen-He Wang、Bruce W. Baldwin、Tadafumi Uchimaru、Kazuyuki Kasuga

  DOI：10.1246/bcsj.72.865

  日期：1999.4

  Transport abilities of alkaline earth, transition, and heavy metal ions were examined for three kinds of disubstituted monoacid derivatives of Kemp’s triacid as transport agents for a liquid membrane system. Diamide derivatives showed high transport ability for CaII over MgII, with selectivity ratios greater than 25. Imide monoacids were also CaII selective. For transition and heavy metal ions, all monoacids including diester monoacid showed very high HgII transport, but with different selectivities depending on the functional group. High HgII/AgI ( = 24), HgII/CuII ( = 194), and HgII/PbII ( = 85) selectivities were observed for diamide, diester, and imide monoacids, respectively. The transport mechanisms are discussed for alkaline earth, transition, and heavy metal ions utilizing ion chromatography analysis of anions co-transported.

  研究了坎普三酸的三种二取代一元酸衍生物作为液膜系统传输剂的碱土金属离子、过渡金属离子和重金属离子的传输能力。二酰胺衍生物对 CaII 的传输能力高于对 MgII 的传输能力，选择性比大于 25。酰亚胺一元酸对 CaII 也具有选择性。对于过渡金属离子和重金属离子，包括二酯一元酸在内的所有一元酸都表现出非常高的 HgII 转运，但根据官能团的不同具有不同的选择性。对于二酰胺、二酯和酰亚胺一元酸，分别观察到高 HgII/AgI (= 24)、HgII/CuII (= 194) 和 HgII/PbII (= 85) 选择性。利用共转运阴离子的离子色谱分析讨论了碱土金属离子、过渡金属离子和重金属离子的转运机制。
• Modification of Kemp’s Triacid to Produce New Ligands Showing Efficient Alkaline Earth Metal Ion Transport with Structure Dependent Selectivity
  作者：Bruce W. Baldwin、Takuji Hirose、Zhen-He Wang、Tadafumi Uchimaru、Ari Yliniemelä

  DOI：10.1246/cl.1996.415

  日期：1996.6

  The calcium/barium selectivity ratio for efficient competitive transport among alkaline earth metal ions was controlled by structural isomerism and side chain linker changes in new lipophilic mono-substituted Kemp’s diacid ionophores.

  碱土金属离子之间有效竞争性运输的钙/钡选择性比受新型亲脂性单取代肯普二酸离子载体的结构异构和侧链接头变化的控制。