ethyl 2-chloro-5-(methylamino)pyrimidine-4-carboxylate | 1365748-92-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: ethyl 2-chloro-5-(methylamino)pyrimidine-4-carboxylate
• CAS: 1365748-92-0
• 化学式: C₈H₁₀ClN₃O₂
• 分子量: 215.639
• InChiKey: HAXOECDCHBOBBY-UHFFFAOYSA-N

物化性质

• 沸点：
  370.5±22.0 °C(Predicted)
• 密度：
  1.333±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 2-chloro-5-(methylamino)pyrimidine-4-carboxylate 在 三乙胺 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 49.0h， 生成 2-chloro-5-methylpyrido[3,2-d]pyrimidine-6,8(5H,7H)-dione
  参考文献：
  名称：

  [EN] QUINOLINES AND AZAQUINOLINES AS INHIBITORS OF CD38
  [FR] QUINOLÉINES ET AZAQUINOLINES EN TANT QU'INHIBITEURS DE CD38

  摘要：

  本发明涉及一种抑制CD38的化合物，可用于治疗癌症。

  公开号：

  WO2022165114A1
• 作为产物：
  描述：

  2-氯-4-(1-乙氧基乙烯基)-5-氟嘧啶 在 potassium permanganate 、 sodium periodate 、 三乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 1.0h， 生成 ethyl 2-chloro-5-(methylamino)pyrimidine-4-carboxylate
  参考文献：
  名称：

  Facile and regioselective synthesis of novel 2,4-disubstituted-5-fluoropyrimidines as potential kinase inhibitors

  摘要：

  2,4-Disubstituted-5-fluoropyrimidine is a biologically active molecular core seen in various anticancer agents such as 5-fluorouracil (5-FU). As part of a programme aimed at discovering kinase inhibitors, routes to two series of novel compounds (5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides) were successfully executed. For the first series, regioselective substitution at the 4-position of the pyrimidine with an amine ((HNRR2)-R-1) was achieved, followed by preparation of the amide at the 2-position. The route to the second series involved introduction of the methoxy protecting group at the 4-position, which allowed subsequent amine substitution to occur at the 2-position. The 4-amide substituent was finally introduced by direct conversion of the 4-methoxy into a 4-chloro group followed by transformation into an amide by palladium catalysis. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.01.088

文献信息

• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20160264536A1

  公开（公告）日：2016-09-15

  The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

  本发明的问题是提供一种具有PDE2A抑制作用的化合物，可用作预防或治疗精神分裂症、阿尔茨海默病等疾病的药物。本发明涉及一种由式（I）表示的化合物：其中每个符号如在说明书中所述，或其盐。
• EP3061754
  申请人：——

  公开号：——

  公开（公告）日：——
• QUINOLINES AND AZAQUINOLINES AS INHIBITORS OF CD38
  申请人：Ribon Therapeutics, Inc.

  公开号：US20220242862A1

  公开（公告）日：2022-08-04

  The present invention relates to compounds which are inhibitors of CD38 and are useful in the treatment of cancer.
• [EN] MULTICYCLIC COMPOUNDS<br/>[FR] COMPOSÉS MULTICYCLIQUES
  申请人：[en]SLAP PHARMACEUTICALS LLC

  公开号：WO2023141522A2

  公开（公告）日：2023-07-27

  Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.