dimethyl 2α,3α-<(dimethylmethylene)dioxy>-5β-tert-butoxy-1β,4β-cyclopentanedicarboxylate | 112576-26-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dimethyl 2α,3α-<(dimethylmethylene)dioxy>-5β-tert-butoxy-1β,4β-cyclopentanedicarboxylate
• CAS: 112576-26-8
• 化学式: C₁₆H₂₆O₇
• 分子量: 330.378
• InChiKey: FGFNGNVCLDGYDO-SSMOUHFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.28
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  80.29
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  dimethyl 2α,3α-<(dimethylmethylene)dioxy>-5β-tert-butoxy-1β,4β-cyclopentanedicarboxylate 在 三氟乙酸 作用下， 反应 0.92h， 以91%的产率得到dimethyl 2α,3α,5β-trihydroxy-1β,4β-cyclopentanedicarboxylate
  参考文献：
  名称：

  Enantioselective hydrolysis of dimethyl 2.alpha.,3.alpha.-[(dimethylmethylene)dioxy]-5.beta.-hydroxy-1.beta.,4.beta.-cyclopentanedicarboxylate with pig liver esterase. Stereoselective synthesis of methyl 2(R),3(S)-[(dimethylmethylene)dioxy]-5(R)-hydroxy-1(S)-carboxy-4(R)-cyclopentanecarboxylate. A cyclopentane synthone with all ring atoms chiral

  摘要：

  DOI：

  10.1021/jo00240a002
• 作为产物：
  描述：

  重氮甲烷 、 2α,3α-<(dimethylmethylene)dioxy>-5β-tert-butoxy-1β,4β-cyclopentadienedicarboxylic acid 以 乙醚 为溶剂， 以50%的产率得到dimethyl 2α,3α-<(dimethylmethylene)dioxy>-5β-tert-butoxy-1β,4β-cyclopentanedicarboxylate
  参考文献：
  名称：

  Enantioselective hydrolysis of dimethyl 2.alpha.,3.alpha.-[(dimethylmethylene)dioxy]-5.beta.-hydroxy-1.beta.,4.beta.-cyclopentanedicarboxylate with pig liver esterase. Stereoselective synthesis of methyl 2(R),3(S)-[(dimethylmethylene)dioxy]-5(R)-hydroxy-1(S)-carboxy-4(R)-cyclopentanecarboxylate. A cyclopentane synthone with all ring atoms chiral

  摘要：

  DOI：

  10.1021/jo00240a002

文献信息

• ZEMLICKA, JIRI;CRAINE, LESLIE E.;HEEG, MARY-JANE;OLIVER, JOHN P., J. ORG. CHEM., 53,(1988) N 5, 937-942
  作者：ZEMLICKA, JIRI、CRAINE, LESLIE E.、HEEG, MARY-JANE、OLIVER, JOHN P.

  DOI：——

  日期：——
• Enantioselective hydrolysis of dimethyl 2.alpha.,3.alpha.-[(dimethylmethylene)dioxy]-5.beta.-hydroxy-1.beta.,4.beta.-cyclopentanedicarboxylate with pig liver esterase. Stereoselective synthesis of methyl 2(R),3(S)-[(dimethylmethylene)dioxy]-5(R)-hydroxy-1(S)-carboxy-4(R)-cyclopentanecarboxylate. A cyclopentane synthone with all ring atoms chiral
  作者：Jiri Zemlicka、Leslie E. Craine、Mary Jane Heeg、John P. Oliver

  DOI：10.1021/jo00240a002

  日期：1988.3