(R)-methyl 3-cyclobutyl-2-hydroxypropanoate | 1235443-43-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-methyl 3-cyclobutyl-2-hydroxypropanoate
• 英文别名: methyl (2R)-3-cyclobutyl-2-hydroxypropanoate
• CAS: 1235443-43-2
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: WYYFNIYZHQBFLB-SSDOTTSWSA-N

物化性质

• 沸点：
  231.2±13.0 °C(Predicted)
• 密度：
  1.106±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三氟甲磺酸酐 、 (R)-methyl 3-cyclobutyl-2-hydroxypropanoate 在 2,6-二甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Substituted Pyrazinone Amides

  摘要：

  本发明提供了式(I)的化合物，这些化合物作为葡萄糖激酶激活剂；其药物组合物；以及治疗由葡萄糖激酶介导的疾病、障碍或状况的方法。变量R1、R2、R3和R4如本文所述。

  公开号：

  US20100184777A1
• 作为产物：
  描述：

  甲醇 、 (R)-3-cyclobutyl-2-hydroxypropanoic acid 在 氯化亚砜 作用下， 反应 0.5h， 生成 (R)-methyl 3-cyclobutyl-2-hydroxypropanoate
  参考文献：
  名称：

  Substituted Pyrazinone Amides

  摘要：

  本发明提供了式(I)的化合物，这些化合物作为葡萄糖激酶激活剂；其药物组合物；以及治疗由葡萄糖激酶介导的疾病、障碍或状况的方法。变量R1、R2、R3和R4如本文所述。

  公开号：

  US20100184777A1

文献信息

• SUBSTITUTED PYRAZINONE AMIDES
  申请人：Pfizer Inc.

  公开号：EP2389374A1

  公开（公告）日：2011-11-30
• Electrical Systems and Battery Assemblies
  申请人：Stone Lawrence

  公开号：US20110254560A1

  公开（公告）日：2011-10-20

  Electrical systems, power supply apparatuses, and power supply operational methods are described. According to one aspect, an electrical system includes an electrical entity configured to utilize electrical energy, and wherein the electrical entity comprises a communications interface, and a power supply apparatus configured to provide the electrical energy for use by the electrical entity, and wherein the power supply apparatus comprises a support system, a plurality of battery assemblies configured to be removably coupled with and supported by the support system, wherein individual ones of the battery assemblies comprise at least one rechargeable electrochemical device configured to provide the electrical energy, at least one power terminal configured to couple with the electrical entity and to provide the electrical energy from the electrochemical device to the electrical entity, and a communications interface configured to implement communications with the communications interface of the electrical entity, and wherein the electrical entity and the power supply apparatus are configured to implement the communications comprising at least one of status information regarding the power supply apparatus from the power supply apparatus to the electrical entity and a command regarding an operation of the power supply apparatus from the electrical entity to the power supply apparatus.
• US8071606B2
  申请人：——

  公开号：US8071606B2

  公开（公告）日：2011-12-06
• [EN] SUBSTITUTED PYRAZINONE AMIDES<br/>[FR] PYRAZINONE AMIDES SUBSTITUÉS
  申请人：PFIZER

  公开号：WO2010084428A1

  公开（公告）日：2010-07-29

  The present invention provides compounds of Formula (I) that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. The variables R1, R2, R3 and R4 are as described herein.
• Substituted Pyrazinone Amides
  申请人：Benbow John William

  公开号：US20100184777A1

  公开（公告）日：2010-07-22

  The present invention provides compounds of Formula (I) that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. The variables R 1 , R 2 , R 3 and R 4 are as described herein.

  本发明提供了式(I)的化合物，这些化合物作为葡萄糖激酶激活剂；其药物组合物；以及治疗由葡萄糖激酶介导的疾病、障碍或状况的方法。变量R1、R2、R3和R4如本文所述。