4-甲基-5-吡啶-4-基-1,3-噻唑-2-甲酰胺 | 106853-15-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-甲基-5-吡啶-4-基-1,3-噻唑-2-甲酰胺
• 中文别名: 1,4-亚甲基-2H-喹嗪,八氢-4-甲基-
• 英文名称: 4-methyl-5-(4-pyridinyl)-thiazole-2-carboxamide
• 英文别名: 4-Methyl-5-(4-pyridinyl)thiazole-2-carboxamide；4-methyl-5-pyridin-4-yl-1,3-thiazole-2-carboxamide
• CAS: 106853-15-0
• 化学式: C₁₀H₉N₃OS
• 分子量: 219.267
• InChiKey: LNMMZMTWCOIELH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  97.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-甲基-5-吡啶-4-基-1,3-噻唑-2-甲酰胺 生成 2-cyano-4-methyl-5-(4-pyridinyl)-thiazole
  参考文献：
  名称：

  TAKASE, MUNEAKI;YOSHIOKA, KIMITOMO;YAMAZAKI, HIROAKI

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 4-methyl-5-(4-pyridinyl)-thiazole-2-carboxylate 以82%的产率得到
  参考文献：
  名称：

  TAKASE, MUNEAKI;YOSHIOKA, KIMITOMO;YAMAZAKI, HIROAKI

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE<br/>[FR] INHIBITEURS DE PHOSPHATIDYLINOSITOL 3-KINASE
  申请人：NOVARTIS AG

  公开号：WO2004096797A1

  公开（公告）日：2004-11-11

  Compounds of formula (I) in free or salt form, wherein R1, R2, R3, and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

  式(I)中的化合物以自由形式或盐形式存在，其中R1、R2、R3和R4的含义如规范中所示，适用于治疗由磷脂酰肌醇3-激酶介导的疾病。还描述了含有这些化合物的药物组合物以及制备这些化合物的过程。
• Thiazole derivatives and medical compositions thereof
  申请人：Zenyaku Kogyo Kabushiki Kaisha

  公开号：US04804668A1

  公开（公告）日：1989-02-14

  A thiazole derivative represented by the formula I, pharmaceutically acceptable acid addition salt thereof, and a process for preparation thereof ##STR1## wherein R.sub.1 represents --COOR.sub.4, ##STR2## or cyano wherein R.sub.4 represents hydrogen or lower alkyl, and R.sub.5 and R.sub.6 may be the same or different and represent hydrogen, lower alkyl, aryl, amino-lower alkyl, N-lower alkylamino-lower alkyl, N,N-di-lower alkylamino-lower alkyl or R.sub.5 and R.sub.6 are joined to form a N-containing heterocyclic group; R.sub.2 represents hydrogen or lower alkyl; and R.sub.3 represents N-containing heterocyclic group. These compounds are useful as cardiotonic agents.

  一种由式I表示的噻唑衍生物，其药学上可接受的酸盐，以及其制备方法。其中，R₁代表--COOR₄，R₂代表氢或较低烷基，R₃代表含氮的杂环基团。这些化合物可用作强心剂。
• Inhibitors of phosphatidylinositol 3-kinase
  申请人：Bruce Ian

  公开号：US20070032487A1

  公开（公告）日：2007-02-08

  Compounds of formula I in free or salt form, wherein R 1 , R 2 , R 3 and R 4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

  公式I的化合物以自由或盐形式存在，其中R1、R2、R3和R4的含义如规范中所示，可用于治疗由磷脂酰肌醇3-激酶介导的疾病。还描述了含有这些化合物的制药组合物以及制备这些化合物的过程。
• Organic compounds
  申请人：Bruce Ian

  公开号：US20100120865A1

  公开（公告）日：2010-05-13

  The present invention concerns a compound of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, wherein the groups Ri-Rs are defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.

  本发明涉及一种式（I）的化合物，或其药学上可接受的盐或溶剂，其中Ri-Rs基团在说明中定义，以及该化合物在治疗通过抑制磷脂酰肌醇3-激酶改善的疾病中的组合物和用途。
• USE OF A PDE 5 INHIBITOR FOR TREATING AND PREVENTING HYPOPIGMENTARY DISORDERS
  申请人：PEUKER Heidemarie

  公开号：US20110142956A1

  公开（公告）日：2011-06-16

  The invention relates to the use of PDE5 inhibitors for treating and/or preventing hypopigmentary disorders.

  本发明涉及使用PDE5抑制剂来治疗和/或预防低色素病。