4-甲基-5-吡啶-4-基-3H-1,3-恶唑-2-酮 | 132338-12-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-甲基-5-吡啶-4-基-3H-1,3-恶唑-2-酮
• 英文名称: MDL 27044
• 英文别名: 4-methyl-5-pyridin-4-yl-2(3H)-oxazolone；4-Methyl-5-(4-pyridinyl)-2(3H)-oxazolone；4-methyl-5-pyridin-4-yl-3H-1,3-oxazol-2-one
• CAS: 132338-12-6
• 化学式: C₉H₈N₂O₂
• 分子量: 176.175
• InChiKey: HYFQYGZLUXYDEG-UHFFFAOYSA-N

物化性质

• 密度：
  1.267±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel pyridyloxazole 2-ones useful as proteinkinase C inhibitors
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0428106A1

  公开（公告）日：1991-05-22

  This invention relates to novel pyridyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma.

  本发明涉及新型吡啶恶唑-2-酮，可用作蛋白激酶 C 抑制剂，有效治疗高血压和哮喘。
• Prevention of glycoprotein enveloped virus infectivity by pyridyloxazole-2-ones
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0428103A2

  公开（公告）日：1991-05-22

  This invention relates to pyridinyloxazole-2-ones which are useful anti-enveloped virus agents by virtue of their ability to act as protein kinase C inhibitors. These derivatives are disclosed to be effective in treating enveloped virus infections including HIV infections and are thus useful in the treatment of AIDS and ARC.

  本发明涉及吡啶并噁唑-2-酮，由于它们能够作为蛋白激酶 C 抑制剂而成为有用的抗包膜病毒制剂。据披露，这些衍生物可有效治疗包膜病毒感染，包括艾滋病病毒感染，因此可用于治疗艾滋病和 ARC。
• Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0428104A2

  公开（公告）日：1991-05-22

  This invention relates to pyridinyloxazole-2-ones which are useful in the treatment of multi-drug resistant tumors. The pyridinyloxazole-2-ones act to prevent drug resistance and thus allow conventional chemotherapeutic agents to kill tumor cells as if drug resistance were not present.

  本发明涉及吡啶恶唑-2-酮，可用于治疗耐多种药物的肿瘤。吡啶并噁唑-2-酮具有防止耐药性的作用，从而使常规化疗药物能够杀死肿瘤细胞，就像不存在耐药性一样。
• Cardiotonic heterocyclic oxazolones
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0222358B1

  公开（公告）日：1991-04-17
• INHIBITION OF METASTASIS IN PATIENTS HAVING CANCER WITH PYRIDYLOXAZOLE-2-ONES
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0539575A1

  公开（公告）日：1993-05-05