(2-{bis-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)ethyl]amino}ethyl)carbamic acid benzyl ester | 1333143-83-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2-{bis-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)ethyl]amino}ethyl)carbamic acid benzyl ester
• 英文别名: benzyl N-[2-[bis[3-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]-3-oxopropyl]amino]ethyl]carbamate
• CAS: 1333143-83-1
• 化学式: C₃₀H₅₀N₆O₈
• 分子量: 622.762
• InChiKey: DGPFPZPEESRFIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.28
• 重原子数：
  44.0
• 可旋转键数：
  17.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  176.43
• 氢给体数：
  5.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  (2-{bis-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)ethyl]amino}ethyl)carbamic acid benzyl ester 在 10% palladium charcoal 、 氢气 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 16.0h， 生成 [2-(3-{[2-(18-azido-octadecanoylamino)ethyl]-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)ethyl]amino}propionylamino)ethyl]carbamic acid tert-butyl ester
  参考文献：
  名称：

  [EN] ANTIDIABETIC COMPOUNDS AND COMPOSITIONS
  [FR] COMPOSES ANTIDIABÉTIQUES ET COMPOSITIONS

  摘要：

  Provided herein are novel compounds (e.g., Formula I, II, II-B, III, or III-B), pharmaceutical compositions, and methods of using related to GPR40. The compounds herein are typically GPR40 agonists, which can be used for treating a variety of disorders, conditions or diseases such as Type 2 diabetes.

  公开号：

  WO2023134712A1
• 作为产物：
  描述：

  N-叔丁氧羰基-1,2-乙二胺 在 三乙胺 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 16.0h， 生成 (2-{bis-[2-(2-tert-butoxycarbonylamino-ethylcarbamoyl)ethyl]amino}ethyl)carbamic acid benzyl ester
  参考文献：
  名称：

  [EN] ANTIDIABETIC COMPOUNDS AND COMPOSITIONS
  [FR] COMPOSES ANTIDIABÉTIQUES ET COMPOSITIONS

  摘要：

  Provided herein are novel compounds (e.g., Formula I, II, II-B, III, or III-B), pharmaceutical compositions, and methods of using related to GPR40. The compounds herein are typically GPR40 agonists, which can be used for treating a variety of disorders, conditions or diseases such as Type 2 diabetes.

  公开号：

  WO2023134712A1

文献信息

• Selective organic functionalization of graphene bulk or graphene edges
  作者：Mildred Quintana、Alejandro Montellano、Antonio Esau del Rio Castillo、Gustaaf Van Tendeloo、Carla Bittencourt、Maurizio Prato

  DOI：10.1039/c1cc13254g

  日期：——

  Graphene sheets have been functionalized with a PAMAM dendron, finding that graphene can be efficiently functionalized all over the surface, or only at the edges, depending on the reactions used in the functionalization process.

  石墨烯片已用 PAMAM 树突进行功能化，发现石墨烯可以在整个表面或仅在边缘有效地功能化，具体取决于功能化过程中使用的反应。
• Synthesis and Characterization of Highly Water-Soluble Dendrofulleropyrrolidine Bisadducts with DNA Binding Activity
  作者：Alejandro Montellano López、Francesco Scarel、Noelia Rubio Carrero、Ester Vázquez、Aurelio Mateo-Alonso、Tatiana Da Ros、Maurizio Prato

  DOI：10.1021/ol301946r

  日期：2012.9.7

  The synthesis, characterization and DNA binding studies of a series of polycationic fullerene adducts are reported. Thew cationic species, exhibiting reasonably high water solubility and a heterogeneous distribution of positive charges, can efficiently complex plasmid DNA. Electrophoresis studies show different DNA binding efficiencies for different adducts, some of which can be considered excellent candidates for DNA binding therapies.