ethyl 9-aminononanoate | 100535-56-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 9-aminononanoate
• CAS: 100535-56-6
• 化学式: C₁₁H₂₃NO₂
• 分子量: 201.309
• InChiKey: FOPQTWQAEWBXBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 9-aminononanoate 以61%的产率得到
  参考文献：
  名称：

  TEMPLE, CARROLL, JR.;ELLIOTT, ROBERT D.;MONTGOMERY, JOHN A., J. MED. CHEM., 31,(1988) N 3, 697-700

  摘要：

  DOI：
• 作为产物：
  描述：

  9-methoxycarbonylamino-nonanoic acid 在 盐酸 作用下， 生成 ethyl 9-aminononanoate
  参考文献：
  名称：

  来自欧米茄氨基酸的聚合酰胺

  摘要：

  描述了由ω-氨基酸制备成纤维的聚合酰胺的方法和聚合的它们的酰胺形成衍生物的熔点变化。讨论了聚合酰胺的熔点随重复单元链长的增加而变化。

  DOI：

  10.1002/pol.1948.120030110

文献信息

• Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2
  作者：Jürgen Vahter、Kaido Viht、Asko Uri、Erki Enkvist

  DOI：10.1016/j.bmc.2017.02.055

  日期：2017.4

  class inhibitor taken to clinical trials. The most potent conjugates possessed two-digit picomolar affinity and clear selectivity for CK2α in a panel of 140 protein kinases. Labeling of the inhibitors with a fluorescent dye yielded probes for a fluorescence anisotropy-based binding/displacement assay which can be used for analysis of CK2 and precise determination of affinity of the highly potent (tight-binding)

  为了调节这种普遍存在的蛋白质以建立催化大量底物蛋白质磷酸化的酶的生物学作用，需要蛋白激酶CK2的结构上多种多样的抑制剂。在本文中，我们公开了一系列新的CK2双底物抑制剂，其结构上由苯并[c] [2,6]萘啶-8-羧酸的寡（1-Asp）肽共轭物表示。该片段源自CX-4945，这是进入临床试验的首个抑制剂。最有效的偶联物在140种蛋白激酶中具有两位数的皮摩尔亲和力和对CK2α的明确选择性。
• Transforming Olefins into <i>γ</i> , <i>δ</i> ‐Unsaturated Nitriles through Copper Catalysis
  作者：Xuesong Wu、Jan Riedel、Vy M. Dong

  DOI：10.1002/anie.201705859

  日期：2017.9.11

  We have developed a strategy to transform olefins into homoallylic nitriles through a mechanism that combines copper catalysis with alkyl nitrile radicals. The radicals are easily generated from alkyl nitriles in the presence of the mild oxidant di‐tert‐butyl peroxide. This cross‐dehydrogenative coupling between simple olefins and alkylnitriles bears advantages over the conventional use of halides

  我们开发了一种策略，通过铜催化与烷基腈自由基相结合的机制，将烯烃转化为均烯丙腈。在温和氧化剂二叔丁基过氧化物存在下，烷基腈很容易产生自由基。这种简单烯烃和烷基腈之间的交叉脱氢偶联比传统使用的卤化物和有毒氰化物试剂具有优势。通过这种方法，我们展示了从简单烯烃轻松合成调味剂、天然产物和聚合物前体的方法。
• Betulinic Acid Derivatives:  A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry
  作者：Françoise Soler、Christèle Poujade、Michel Evers、Jean-Christophe Carry、Yvette Hénin、Anne Bousseau、Thierry Huet、Rudi Pauwels、Erik De Clercq、Jean-François Mayaux、Jean-Bernard Le Pecq、Norbert Dereu

  DOI：10.1021/jm950669u

  日期：1996.1.1

  A novel series of omega-aminoalkanoic acid derivatives of betulinic acid were synthesized and evaluated for their activity against human immunodeficiency virus (HIV). The anti-HIV-1 activity of several members of this new series was found to be in the nanomolar range in CEM 4 and MT-4 cell cultures. The optimization of the omega-aminoalkanoic acid side chain is described. The presence of an amide function within the side chain was found important for optimal activity. RPR 103611 (14g), a statine derivative, was found to be inactive against HIV-1 protease, reverse transcriptase, and integrase as well as on gp120/CD4 binding. ''Time of addition'' experiments suggested interaction with an early step of HIV-1 replication. As syncytium formation, but not virus-cell binding, seems to be affected, betulinic acid derivatives are assumed to interact with the postbinding virus-cell fusion process.
• Process for the production of omegaamino acids
  申请人：HIROSHI OTSUKI

  公开号：US02862940A1

  公开（公告）日：1958-12-02
• TEMPLE, CARROLL, JR.;ELLIOTT, ROBERT D.;MONTGOMERY, JOHN A., J. MED. CHEM., 31,(1988) N 3, 697-700
  作者：TEMPLE, CARROLL, JR.、ELLIOTT, ROBERT D.、MONTGOMERY, JOHN A.

  DOI：——

  日期：——