4-(3-chlorophenyl)-1,-butylamine | 181650-48-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-chlorophenyl)-1,-butylamine
• 英文别名: 4-(3-chlorophenyl)butan-1-amine
• CAS: 181650-48-6
• 化学式: C₁₀H₁₄ClN
• 分子量: 183.681
• InChiKey: TUCKGJZYCMYNAP-UHFFFAOYSA-N

物化性质

• 熔点：
  100-102 °C
• 沸点：
  280.9±23.0 °C(Predicted)
• 密度：
  1.074±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(3-chlorophenyl)-1,-butylamine 在 甲醇 作用下， 以 水 、 乙腈 为溶剂， 反应 20.0h， 生成
  参考文献：
  名称：

  Synthesis and Antibacterial Activity of Ketolides (6-O-Methyl-3-oxoerythromycin Derivatives):  A New Class of Antibacterials Highly Potent Against Macrolide-Resistant and -Susceptible Respiratory Pathogens

  摘要：

  In the search for new antibiotics active against macrolide-resistant pneumococci and Haemophilus influenzae, we synthesized a new class of 3-oxo-6-O-methylerythromycin derivatives, so-called "ketolides". A keto function was introduced in position 3 after removal of L-cladinose, a sugar which has long been thought essential. Further modifications of the macrolactone backbone allowed us to obtain three different series of 9-oxime, 11,12-carbamate, and 11,12-hydrazonocarbamate ketolides. These compounds were found to be very active against penicillin/erythromycin-resistant pneumococci and noninducers of MLS(B) resistance. The 11,12-substituted ketolide 61 (HMR 3004) demonstrated a potent activity against multiresistant pneumococci associated with a well-balanced activity against all bacteria involved in respiratory infections including H. influenzae, Mycoplasma catarrhalis, group A streptococci, and atypical bacteria. In addition HMR 3004 displayed high therapeutic activity in animals infected by all major strains, irrespective of their resistance phenotype.

  DOI：

  10.1021/jm980240d
• 作为产物：
  描述：

  (3-(1,3-dioxoisoindolin-2-yl)propyl)triphenylphosphonium bromide 在 platinum(IV) oxide potassium tert-butylate 、 氢气 、 一水合肼 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 为溶剂， 反应 1.58h， 生成 4-(3-chlorophenyl)-1,-butylamine
  参考文献：
  名称：

  [EN] 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES
  [FR] DÉRIVÉS DE L'ACIDE CARBOXYLIQUE PHÉNOXYCHROMANE SUBSTITUÉS EN 6

  摘要：

  式（I）的化合物：其中A1、A2、W、L、G、R7a、R7b、R8、R9和R10具有规范中给定的含义，是DP2受体调节剂，可用于治疗免疫性疾病。

  公开号：

  WO2009158426A1

文献信息

• [EN] PYRAZINE-BASED TUBULIN INHIBITORS<br/>[FR] INHIBITEURS DE TUBULINE A BASE DE PYRAZINE
  申请人：CYTOPIA PTY LTD

  公开号：WO2004052868A1

  公开（公告）日：2004-06-24

  A compound of general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating a hyperproliferation-related disease state or disorder in a subject using a compound of formula (I) is also described.

  描述了一种具有通式（I）或药用可接受的前药、盐、水合物、溶剂合物、晶型或对映体的化合物。还描述了一种使用通式（I）化合物治疗受试者的过度增殖相关疾病状态或紊乱的方法。
• Method of treating tuberculosis
  申请人：Falzari Kanakeshwari

  公开号：US20050014706A1

  公开（公告）日：2005-01-20

  Macrolide and ketolides, and compositions containing the same, useful in the treatment of tuberculosis are disclosed. Methods of treating tuberculosis using the macrolides and ketolides, and compositions containing the same, also are disclosed.

  揭示了用于治疗结核病的大环内酯类和酮内酯类药物，以及包含它们的组合物。还公开了使用大环内酯类和酮内酯类药物以及包含它们的组合物治疗结核病的方法。
• Enantioselective Copper-Catalyzed Remote C(sp³)–H Alkynylation of Linear Primary Sulfonamides
  作者：Cheng-Yu Wang、Zi-Yang Qin、Yu-Ling Huang、Yi-Ming Hou、Ruo-Xing Jin、Chao Li、Xi-Sheng Wang

  DOI：10.1021/acs.orglett.0c01325

  日期：2020.5.15

  The highly efficient copper-catalyzed enantioselective alkynylation of the remote C(sp3)-H bond on linear primary sulfonamides is presented here using a radical relay strategy. The chiral box-copper complex, which is used to recapture the in-situ-generated alkyl radical via a 1,5-HAT strategy, is the key to success, affording the chiral alkynes after a following reductive elimination. A general substrate

  此处使用自由基中继策略介绍了高效的铜催化线性伯磺酰胺上远程C（sp3）-H键的铜对映体选择性炔基化反应。手性盒铜配合物是成功的关键，该手性盒铜配合物可通过1，5-HAT策略重新捕获原位生成的烷基，在还原反应消除后得到手性炔烃。该方法证明了一般的底物范围，温和的条件以及出色的区域和对映选择性控制。
• 2-(aminomethyl) arylamide analgesics
  申请人：PHARMACOPEIA, INC

  公开号：US20040167119A1

  公开（公告）日：2004-08-26

  A chemical genus of 2-(aminomethyl)arylamides, which are useful as analgesics, is disclosed. The genus is represented by the formula I: 1 A representative example is: 2

  本发明揭示了一种2-(氨甲基)芳基酰胺的化学类，其作为镇痛剂具有用途。该类别由公式I表示：1。代表性的例子为：2。
• METHOD FOR PRODUCING BIARYL COMPOUND
  申请人：Sato Koichi

  公开号：US20100087680A1

  公开（公告）日：2010-04-08

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种制备双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱的存在下，将芳香有机化合物与选自芳香基有机硼化合物和硼氧化物化合物组的至少一种化合物反应。