3,6,2'-trihydroxyflavone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3,6,2'-trihydroxyflavone
• 英文别名: 2',3,6-trihydroxyflavone；3,6-dihydroxy-2-(2-hydroxy-phenyl)-chromen-4-one；3,6-Dihydroxy-2-(2-hydroxy-phenyl)-chromen-4-on；3,6-dihydroxy-2-(2-hydroxyphenyl)chromen-4-one
• 化学式: C₁₅H₁₀O₅
• 分子量: 270.241
• InChiKey: SLPZPKKKEQCKDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,6,2'-trihydroxyflavone 、 硫酸二甲酯 在 甲醇 、 sodium hydroxide 作用下， 生成 6,2'-Dimethoxy-3-hydroxyflavone
  参考文献：
  名称：

  Vyas; Shah, Proceedings - Indian Academy of Sciences, Section A, 1950, # 32, p. 386,387

  摘要：

  DOI：
• 作为产物：
  描述：

  (E)-1-(2,5-dihydroxyphenyl)-3-(2-hydroxyphenyl)-2-propen-1-one 在 sodium hydroxide 、 双氧水 作用下， 生成 3,6,2'-trihydroxyflavone
  参考文献：
  名称：

  Vyas; Shah, Proceedings - Indian Academy of Sciences, Section A, 1950, # 32, p. 386,387

  摘要：

  DOI：

文献信息

• Green access to flavonols by one-pot serial aldol condensation/Algar–Flynn–Oyamada reaction catalyzed using the new bio-based catalyst of alkaline amylopectin
  作者：Fatemeh Tamaddon、Hossein Rashidi

  DOI：10.1007/s11164-023-05138-9

  日期：2023.12

  Herein, alkaline amylopectin (AAp) was prepared under chemo-mechanically dry conditions, characterized by base capacity, FT-IR, FESEM, TEM, and TGA analyses, and held as a new bio-organic base catalyst in the one-pot synthesis of flavonols. With a base capacity of 7.3 mmolHO−/g, AAp catalyzed initial aldol condensation and further Algar–Flynn–Oyamada reaction in cooperation with hydrogen peroxide to

  在此，在化学机械干燥条件下制备碱性支链淀粉（AAp），通过碱容量、FT-IR、FESEM、TEM 和 TGA 分析进行表征，并作为新型生物有机碱催化剂用于一锅合成黄酮醇。基本容量为 7.3 mmolH2O -/g，AAp 催化初始羟醛缩合，并与过氧化氢配合进一步进行 Algar-Flynn-Oyamada 反应，得到高产率的黄酮醇抗氧化剂。因此，原位形成的2'-羟基查耳酮的第一次羟醛缩合或随后的氧化环化/羟基化在锅中成功进行，形成黄酮醇产品，而没有橙酮副产物。发现超分子碱催化剂AAp在重复使用五次后结构得到了很好的保存。该方案的优点是反应物可用、无苯醌副产物、反应时间短、产率高和催化剂可重复使用。 图形概要
• Katschalowsky; v. Kostanecki, Chemische Berichte, 1904, vol. 37, p. 2348
  作者：Katschalowsky、v. Kostanecki

  DOI：——

  日期：——
• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.