(S)-[(3aR,5S,6R,6aR)-2,2,6-trimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]-[(2R,3S,6S,8R,9S)-8-[(2S)-2,4-bis(phenylmethoxy)butyl]-3-methoxy-9-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]methanol | 1063743-59-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-[(3aR,5S,6R,6aR)-2,2,6-trimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]-[(2R,3S,6S,8R,9S)-8-[(2S)-2,4-bis(phenylmethoxy)butyl]-3-methoxy-9-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]methanol
• CAS: 1063743-59-8
• 化学式: C₃₈H₅₄O₉
• 分子量: 654.841
• InChiKey: XKLJYVJWVUGACI-JUZFEUDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  47
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  94.1
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  甲醇 、 (1S,7S,8R,10S)-10,12-bis(benzyloxy)-8-(tert-butyldimethylsilyloxy)-1-((4S,5S)-2,2-dimethyl-5-((3aR,5S,6R,6aR)-2,2,6-trimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-1,3-dioxolan-4-yl)-1-methoxy-7-methyldodecan-4-one 在 硫酸 作用下， 以 水 为溶剂， 反应 12.0h， 生成 、 、 (S)-[(3aR,5S,6R,6aR)-2,2,6-trimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]-[(2R,3S,6S,8R,9S)-8-[(2S)-2,4-bis(phenylmethoxy)butyl]-3-methoxy-9-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]methanol
  参考文献：
  名称：

  Spirastrellolide B: The Synthesis of Southern (C₉−C₂₅) Region

  摘要：

  A combination of ''chiron" and "asymmetric" approaches is utilized to construct the southern (C-9-C-25) region of marine natural product spirastrellolide B. The key functionalities are derived from D-glucose and Sharpless asymmetric epoxidation and dihydroxylation.

  DOI：

  10.1021/ol801771s

文献信息

• Spirastrellolide B: The Synthesis of Southern (C₉−C₂₅) Region
  作者：Srivari Chandrasekhar、Chegondi Rambabu、Annareddy Syamprasad Reddy

  DOI：10.1021/ol801771s

  日期：2008.10.2

  A combination of ''chiron" and "asymmetric" approaches is utilized to construct the southern (C-9-C-25) region of marine natural product spirastrellolide B. The key functionalities are derived from D-glucose and Sharpless asymmetric epoxidation and dihydroxylation.