N-desmethyl-N-(2-hydroxypropyl)-cyclobutyl-(9S)-dihydroerythromycin A | 916242-78-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-desmethyl-N-(2-hydroxypropyl)-cyclobutyl-(9S)-dihydroerythromycin A
• 英文别名: (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-14-ethyl-7,10,12,13-tetrahydroxy-6-((2S,3R,4S,6R)-3-hydroxy-4-(((S)-2-hydroxypropyl)(methyl)amino)-6-methyltetrahydro-2H-pyran-2-yloxy)-4-((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yloxy)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one；(3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-14-ethyl-7,10,12,13-tetrahydroxy-6-[(2S,3R,4S,6R)-3-hydroxy-4-[[(2S)-2-hydroxypropyl]-methylamino]-6-methyloxan-2-yl]oxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
• CAS: 916242-78-9
• 化学式: C₃₉H₇₃NO₁₄
• 分子量: 780.007
• InChiKey: XKDBKVQGKLXZNJ-IPPRFSLISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  54
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  217
• 氢给体数：
  7
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  9-dihydro-N-desmethylerythromycin A 、 S-环氧丙烷 以 甲醇 为溶剂， 反应 24.0h， 生成 N-desmethyl-N-(2-hydroxypropyl)-cyclobutyl-(9S)-dihydroerythromycin A
  参考文献：
  名称：

  Motilide compounds

  摘要：

  具有如公式（I）所示结构的化合物，其中RA、RB、RC、RD、RE和RF的定义如本文所述，可用作促动力剂。

  公开号：

  US20060270616A1

文献信息

• Motilide compounds
  申请人：Liu Yaoquan

  公开号：US20060270616A1

  公开（公告）日：2006-11-30

  Compounds having a structure according to formula (I) where R A , R B , R C , R D , R E , and R F are as defined herein, are useful as prokinetic agents.

  具有如公式（I）所示结构的化合物，其中RA、RB、RC、RD、RE和RF的定义如本文所述，可用作促动力剂。
• MOTILIDE COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1888082B1

  公开（公告）日：2012-09-12
• US7582611B2
  申请人：——

  公开号：US7582611B2

  公开（公告）日：2009-09-01
• 9-Dihydroerythromycins as non-antibiotic motilin receptor agonists
  作者：Yaoquan Liu、Yong Li、Yue Chen、Hao Zheng、Mark Claypool、David C. Myles、Christopher W. Carreras

  DOI：10.1016/j.bmcl.2010.08.030

  日期：2010.10

  A series of 9-dihydroerythromycin A and B analogues with modification of the desosamine nitrogen have been synthesized and screened for motilin agonist activity, antibiotic activity, tachyphylaxis and hERG channel current inhibition. Small alkyl groups resulted in the potency while compounds with a primary or secondary amine resulted in the low motilin agonist potency. Several compounds were identified as non-antibiotic motilin receptor agonists with minimal tachyphylaxis and low hERG interaction. (C) 2010 Elsevier Ltd. All rights reserved.