6-[(3,5-diacetylphenyl)amino]purine | 180741-04-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-[(3,5-diacetylphenyl)amino]purine
• 英文别名: 1-[3-acetyl-5-(7H-purin-6-ylamino)phenyl]ethanone
• CAS: 180741-04-2
• 化学式: C₁₅H₁₃N₅O₂
• 分子量: 295.301
• InChiKey: ALUBGINUXJVJKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,5-diacetyl aniline 、 6-氯嘌呤 在 盐酸 、 氢氧化钾 作用下， 以 水 为溶剂， 生成 6-[(3,5-diacetylphenyl)amino]purine
  参考文献：
  名称：

  Pyrimidine compounds and methods of use to derivatize neighboring lysine

  摘要：

  一种化合物的化学式为：##STR1## 其中A=CH.sub.3或CH.sub.2 CH.sub.3和##STR2## 其中X=NH.sub.2、CH.sub.2或CH.sub.2 CH.sub.3；X'=CH.sub.3或CH.sub.2 CH.sub.3；Y=NH.sub.2、NHCH.sub.3、N(CH.sub.3).sub.2；Z=H、CH.sub.3或CH.sub.2 CH.sub.3；或##STR3## 其中Y'和Z'独立地=H、NH.sub.2、NHCH.sub.3、N(CH.sub.3).sub.2或N.sup.+ (CH.sub.3).sub.3；及其盐。

  公开号：

  US05574040A1

文献信息

• Compounds for treating infectious diseases
  申请人：The Picower Institute for Medical Research

  公开号：US05840893A1

  公开（公告）日：1998-11-24

  There is disclosed compound according to the formula: ##STR1## wherein A, independently,=CH.sub.3 or CH.sub.2 CH.sub.3, P=1 or 2; and ##STR2## wherein X=NH.sub.2, CH.sub.3 or CH.sub.2 CH.sub.3 ; X'=CH.sub.3 or CH.sub.2 CH.sub.3 ; Y=NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2 ; and Z=H, CH.sub.3 or CH.sub.2 CH.sub.3 ; or ##STR3## wherein Y' and Z', independently,=H, NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2 or N.sup.+ (CH.sub.3).sub.3 ; Q is N or CH; and salts thereof.

  公开了一种化合物，其化学式为：##STR1## 其中，A独立地等于CH.sub.3或CH.sub.2 CH.sub.3，P等于1或2；以及##STR2## 其中，X等于NH.sub.2，CH.sub.3或CH.sub.2 CH.sub.3；X'等于CH.sub.3或CH.sub.2 CH.sub.3；Y等于NH.sub.2，NHCH.sub.3，N(CH.sub.3).sub.2；Z等于H，CH.sub.3或CH.sub.2 CH.sub.3；或##STR3## 其中，Y'和Z'独立地等于H，NH.sub.2，NHCH.sub.3，N(CH.sub.3).sub.2或N.sup.+ (CH.sub.3).sub.3；Q为N或CH；以及其盐。
• Compounds and methods of use to treat infectious diseases
  申请人：The Picower Institute For Medical Research

  公开号：US06297253B1

  公开（公告）日：2001-10-02

  The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into the nucleus of a cell. The invention encompasses methods of use of such compounds for treatment or prevention of infectious diseases, such as parasitic and viral diseases, including, for example, malaria and acquired immunodeficiency syndrome. The use of the compounds to detect certain specific protein structures which are present in nuclear localization sequences is also taught.

  本发明涉及具有抗感染活性的烷基芳基羰基化合物。本发明的化合物可以用于靶向特定的核定位信号，从而阻止特定蛋白质或分子复合物进入细胞核。本发明涵盖了使用这些化合物治疗或预防传染病的方法，例如寄生虫和病毒性疾病，包括疟疾和获得性免疫缺陷综合症。还教授了使用这些化合物检测存在于核定位序列中的某些特定蛋白质结构的方法。
• Compounds and methods of use to derivatize neighboring lysine residues
  申请人：The Picower Institute for Medical Research

  公开号：US05733932A1

  公开（公告）日：1998-03-31

  The present invention encompasses the use of the compounds of formula as given below to detect certain specific protein structures which are present in nuclear localization sequences ##STR1## wherein A is, independently CH.sub.3 or CH.sub.2 CH.sub.3 and R is ##STR2## and salts thereof.

  本发明涵盖使用以下公式的化合物来检测存在于核定位序列中的某些特定蛋白质结构：##STR1## 其中A独立地表示CH.sub.3或CH.sub.2 CH.sub.3，R表示##STR2##及其盐。
• Compounds and Methods Used to Treat Infectious Diseases
  申请人：Bukrinsky Michael I.

  公开号：US20100137566A1

  公开（公告）日：2010-06-03

  The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into the nucleus of a cell. The invention encompasses methods of use of such compounds for treatment or prevention of infectious diseases, such as parasitic and viral diseases, including, for example, malaria and acquired immunodeficiency syndrome. The use of the compounds to detect certain specific protein structures which are present in nuclear localization sequences is also taught.

  本发明涉及具有抗感染活性的烷基芳基羰基化合物。本发明的化合物可用于针对特定的核定位信号，从而阻止特定蛋白质或分子复合物进入细胞核。本发明涵盖了使用这些化合物治疗或预防传染病的方法，例如寄生虫和病毒性疾病，包括疟疾和获得性免疫缺陷综合症。本发明还教导了使用这些化合物检测存在于核定位序列中的某些特定蛋白质结构的方法。
• COMPOUNDS AND THEIR USE TO TREAT INFECTIOUS DISEASES
  申请人：THE PICOWER INSTITUTE FOR MEDICAL RESEARCH

  公开号：EP0865434B1

  公开（公告）日：2003-12-17