十八碳-8,10,12-三炔酸 | 203399-13-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 十八碳-8,10,12-三炔酸
• 英文名称: octadeca-8,10,12-triynoic acid
• 英文别名: 8,10,12-Octadecatriynoic acid
• CAS: 203399-13-7
• 化学式: C₁₈H₂₄O₂
• 分子量: 272.387
• InChiKey: ZRDMQHHJJMWDNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-碘-1-庚炔 在 四氢吡咯 、 chromium(VI) oxide 、 sodium hydroxide 、 copper(l) iodide 、 正丁基锂 、 硫酸 、 碘 作用下， 以 四氢呋喃 、 xylene 为溶剂， 生成 十八碳-8,10,12-三炔酸
  参考文献：
  名称：

  Synthesis of Polyacetylenic Acids Isolated from Heisteria acuminata

  摘要：

  [GRAPHICS]Four linear polyacetylenic compounds were synthesized. Pentadeca-6,8,10-triynoic acid 1 and octadeca-8,10,12-triynoic acid 2 were synthesized by using acetylene coupling reactions. The syntheses of (Z)-hexadec-11-en-7,9-diynoic acid 3 and (Z)-octadec-12-en-7,9-diynoic acid 4 by using vinylic telluride coupling reactions were accomplished.

  DOI：

  10.1021/ol006946v

文献信息

• Pharmaceutical composition comprising lipids comprising a polar and a nonpolar moiety
  申请人：——

  公开号：US20040219202A1

  公开（公告）日：2004-11-04

  The present invention provides a composition comprising (i) a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein the non-polar moiety is of the formula X-Y-Z- wherein X is an acetylenic hydrocarbyl group containing a single C≡C bond, Y is O or CH 2 , and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula -[T] m PHG, wherein [T] m is an optional group selected from C(O), NH, NR 1 , NHC(O), C(O)NH, NRIC(O) and C(O)NR 1 and CH 2 , where R 1 is a hydrocarbyl group, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties (ii) a therapeutic agent.

  本发明提供了一种组合物，包括（i）脂质化合物，其包括至少一个非极性基团和一个极性基团，其中非极性基团的化学式为X-Y-Z-，其中X是含有单个C≡C键的乙炔基烃基团，Y是O或CH2，Z是可选的烃基团，极性基团的化学式为-[T] m PHG，其中[T] m是可选的基团，选自C（O）、NH、NR1、NHC（O）、C（O）NH、NRIC（O）和C（O）NR1和CH2，其中R1是烃基团，PHG是极性头基团，m是非极性基团的数量；（ii）一种治疗剂。
• PHARMACEUTICAL COMPOSITION COMPRISING LIPIDS WITH A POLAR AND A NONPOLAR MOIETY
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP1411898A1

  公开（公告）日：2004-04-28
• [EN] PHARMACEUTICAL COMPOSITION COMPRISING LIPIDS COMPRISING A POLAR AND A NONPOLAR MOIETY<br/>[FR] COMPOSITION PHARMACEUTIQUE RENFERMANT DES LIPIDES COMPRENANT UNE FRACTION POLAIRE AINSI QU'UNE FRACTION NON POLAIRE
  申请人：MITSUBISHI CHEM CORP

  公开号：WO2003011252A1

  公开（公告）日：2003-02-13

  The present invention provides a composition comprising (i) a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein the non-polar moiety is of the formula X-Y-Z- wherein X is an acetylenic hydrocarbyl group containing a single C C bond, Y is O or CH2, and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula -[T]mPHG, wherein [T]m is an optional group selected from C(O), NH, NR1, NHC(O), C(O)NH, NR1C(O) and C(O)NR1 and CH2, where R1 is a hydrocarbyl group, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties (ii) a therapeutic agent.
• Synthesis of Polyacetylenic Acids Isolated from <i>Heisteria</i> <i>a</i><i>cuminata</i>
  作者：Gilson Zeni、Rodrigo B. Panatieri、Eliseo Lissner、Paulo H. Menezes、Antonio L. Braga、Hélio A. Stefani

  DOI：10.1021/ol006946v

  日期：2001.3.1

  [GRAPHICS]Four linear polyacetylenic compounds were synthesized. Pentadeca-6,8,10-triynoic acid 1 and octadeca-8,10,12-triynoic acid 2 were synthesized by using acetylene coupling reactions. The syntheses of (Z)-hexadec-11-en-7,9-diynoic acid 3 and (Z)-octadec-12-en-7,9-diynoic acid 4 by using vinylic telluride coupling reactions were accomplished.