1,1′-biphenyl-3,5-diamine | 91391-76-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1′-biphenyl-3,5-diamine
• 英文别名: 3,5-Diamino-biphenyl；5-Phenylbenzene-1,3-diamine
• CAS: 91391-76-3
• 化学式: C₁₂H₁₂N₂
• 分子量: 184.241
• InChiKey: ABAPNKBSVNXXPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1′-biphenyl-3,5-diamine 、 对甲氧基苯磺酰氯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 3N,N'-(1,1′-biphenyl-3,5-diyl)bis(4-methoxybenzenesulfonamide)
  参考文献：
  名称：

  Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors

  摘要：

  Activators of nuclear factor-erythroid 2-related factor 2 (NRF2) could lead to promising therapeutics for prevention and treatment of oxidative stress and inflammatory disorders. Ubiquitination and subsequent degradation of the transcription factor NRF2 is mediated by Kelch-like ECH-associated protein-1 (KEAP1). Inhibition of the KEAP1/NRF2 interaction with small molecules leads to NRF2 activation. Previously, we and others described naphthalene-based NRF2 activators, but the 1,4-diaminonaphthalene scaffold may not represent a drug-like scaffold. Paying particular attention to aqueous solubility, metabolic stability, potency, and mutagenicity, we modified a previously known, naphthalene-based nonelectrophilic NRF2 activator to give a series of non-naphthalene and heterocyclic scaffolds. We found that, compared to previously reported naphthalene-based compounds, a 1,4-isoquinoline scaffold provides a better mutagenic profile without sacrificing potency, stability, or solubility.

  DOI：

  10.1021/acs.jmedchem.8b01133
• 作为产物：
  描述：

  1,3-二硝基-5-苯基苯 在 盐酸 、 tin(ll) chloride 作用下， 以 乙醇 为溶剂， 生成 1,1′-biphenyl-3,5-diamine
  参考文献：
  名称：

  Dieteren,H.M.L.; Koningsberger,C., Recueil des Travaux Chimiques des Pays-Bas, 1963, vol. 82, p. 5 - 16

  摘要：

  DOI：

文献信息

• [EN] NOVEL ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME<br/>[FR] NOUVEAUX COMPOSÉS ÉLECTROLUMINESCENTS ORGANIQUES ET DISPOSITIF ÉLECTROLUMINESCENT ORGANIQUE LES UTILISANT
  申请人：ROHM & HAAS ELECT MAT

  公开号：WO2011099718A1

  公开（公告）日：2011-08-18

  Provided are novel organic electroluminescent compounds and an organic electroluminescent device using the same. Since the organic electroluminescent compound exhibits good luminous efficiency and excellent life property compared to the existing host material, it may be used to manufacture OLED devices having very superior operation life and consuming less power due to improved power efficiency.

  提供的是新型有机电致发光化合物以及使用该化合物的有机电致发光设备。由于该有机电致发光化合物与现有主体材料相比展现出良好的发光效率和卓越的寿命特性，因此可以用来制造具有非常优越的操作寿命和更低功耗的OLED设备，这是由于提高了功率效率。
• SUBSTITUTED PHENYL-SPLEEN TYROSINE KINASE (SYK) INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150232428A1

  公开（公告）日：2015-08-20

  The invention provides certain substituted phenyl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R cy , and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).

  本发明提供了公式(I)或其药学上可接受的盐的某些取代苯基化合物，其中R1、R2、R3、R4、Rcy和t如本文中所定义。本发明还提供了包括这些化合物的制药组合物以及使用这些化合物治疗Spleen Tyrosine Kinase（Syk）介导的疾病或病症的方法。
• Liquid crystal display device
  申请人：SHARP KABUSHIKI KAISHA

  公开号：US11053354B2

  公开（公告）日：2021-07-06

  The present invention provides a liquid crystal display device with a high degree of freedom in molecular structure design of an alignment film and with reduced image sticking. The liquid crystal display device includes a pair of substrates; a liquid crystal layer held between the substrates; an alignment film disposed on a liquid crystal layer side surface of at least one of the substrates; and a polymer layer disposed between the liquid crystal layer and the alignment film, the alignment film containing a first polymer containing at least one structure represented by the following formula (1) in a side chain, wherein R1 represents a C3-C6 branched or cyclic alkylene group, and a hydrogen atom at a para position to a carbonyl group in the phenyl group is optionally replaced.

  本发明提供了一种液晶显示装置，其对准膜的分子结构设计自由度很高，并能减少图像粘连。该液晶显示装置包括一对基板；夹持在基板之间的液晶层；设置在至少其中一个基板的液晶层侧表面上的对准膜；以及设置在液晶层和对准膜之间的聚合物层，对准膜含有第一种聚合物，其侧链中至少含有一种由下式(1)表示的结构、 其中 R1 代表 C3-C6 支链或环状亚烷基，苯基中对位至羰基的氢原子可选择被取代。
• Dieteren,H.M.L.; Koningsberger,C., Recueil des Travaux Chimiques des Pays-Bas, 1963, vol. 82, p. 5 - 16
  作者：Dieteren,H.M.L.、Koningsberger,C.

  DOI：——

  日期：——
• Substituted m-phenylenediamines
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0082258B1

  公开（公告）日：1986-02-19