methyl (2S)-2-amino-3-(4-prop-2-ynoxyphenyl)propanoate | 1044548-57-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-amino-3-(4-prop-2-ynoxyphenyl)propanoate
• CAS: 1044548-57-3
• 化学式: C₁₃H₁₅NO₃
• 分子量: 233.267
• InChiKey: CXQZZKFKFJPKDU-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl (2S)-2-amino-3-(4-prop-2-ynoxyphenyl)propanoate 在 N-甲基吗啉 、 盐酸 、 N-羟基-7-氮杂苯并三氮唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.16h， 生成
  参考文献：
  名称：

  CuAAC Macrocyclization: High Intramolecular Selectivity through the Use of Copper–Tris(triazole) Ligand Complexes

  摘要：

  A range of multivalent heteroaryl ligands, copper sources, and solvent systems have been Investigated for use in CuAAC-mediated macrocyclization reactions. These studies have revealed the key factors governing selectivity for macrocyclization versus dimerization and identified a simple but specific set of reaction conditions capable of efficiently generating a diverse series of drug-like macrocycles at modest dilution in up to 95% yield.

  DOI：

  10.1021/ol200861f
• 作为产物：
  描述：

  Boc-L-酪氨酸甲酯 在 盐酸 、 potassium carbonate 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 methyl (2S)-2-amino-3-(4-prop-2-ynoxyphenyl)propanoate
  参考文献：
  名称：

  一种苦参碱衍生物纳米颗粒及其制备方法和应用

  摘要：

  本发明公开了一种苦参碱衍生物纳米颗粒及其制备方法和应用，属于医药技术领域。本发明基于苦参碱进行结构改造，合成了一种新的苦参碱衍生物(LST‑4)。在此基础上，进一步自组装制备纳米颗粒(LST‑4NPs)。本发明反应条件温和，纳米粒子粒径均一稳定。所述材料苦参碱衍生物纳米颗粒LST‑4NPs可顺利进入细胞，抑制肿瘤细胞的增殖。LST‑4NPs进入细胞后，聚集在溶酶体，提高了药物的生物利用度；LST‑4NPs与LST‑4相比，增强了EPR效应，在肿瘤治疗方面，LST‑4NPs具有更好的治疗效果。

  公开号：

  CN116874487A

文献信息

• [EN] MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS<br/>[FR] COMPOSÉS MACROCYCLIQUES POUR L'INHIBITION D'INHIBITEURS DE L'APOPTOSE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014074658A1

  公开（公告）日：2014-05-15

  There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

  这里公开了调节凋亡抑制剂（IAPs）活性的化合物，包含所述化合物的药物组合物以及使用本发明的化合物治疗增殖性疾病和凋亡失调疾病的方法，例如癌症。
• Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues
  作者：Shubo Du、Danyang Wang、Jun-Seok Lee、Bo Peng、Jingyan Ge、Shao Q. Yao

  DOI：10.1039/c7cc04536k

  日期：——

  We have developed a versatile antibody-assisted strategy for the imaging and profiling of newly synthesized proteomes in a cell-specific manner. This strategy remained highly selective even in heterogeneous co-cultured cells, thus enabling labeling and enrichment of nascent proteomes from targeted cells without the need for physical separation.

  我们已经开发了一种通用的抗体辅助策略，用于以细胞特异性方式对新合成的蛋白质组进行成像和分析。即使在异质共培养细胞中，该策略仍具有很高的选择性，因此无需物理分离就可以标记和富集来自靶细胞的新生蛋白质组。
• New β-Strand Templates Constrained by Huisgen Cycloaddition
  作者：Ashok D. Pehere、Andrew D. Abell

  DOI：10.1021/ol3002199

  日期：2012.3.2

  New peptidic templates constrained into a beta-strand geometry by linking acetylene and azide containing P-1 and P-3 residues of a tripeptide by Huisgen cycloaddition are presented. The conformations of the macrocycles are defined by NMR studies and those that best define a beta-strand are shown to be potent inhibitors of the protease calpain. The beta-strand templates presented and defined here are prepared under optimized conditions that should be suitable for targeting a range of proteases and other applications requiring such a geometry.
• Non-enzymatic Covalent Protein Labeling Using a Reactive Tag
  作者：Hiroshi Nonaka、Shinya Tsukiji、Akio Ojida、Itaru Hamachi

  DOI：10.1021/ja074176d

  日期：2007.12.1

  We describe herein a new method for covalent labeling of proteins using a complementary recognition pair of peptide tag and synthetic molecular probe. The rapid and specific covalent labeling of a tag-fused protein was achieved by the reaction on the tag site with the probe through their selective molecular recognition. The advantages of this method involve the facile functional modification and the high labeling specificity of the tag-fused protein, which are demonstrated in the labeling experiments in various conditions even inside cells.
• CATALYST IMMOBILIZATION ON SILICEOUS MESOCELLULAR FOAM VIA CLICK CHEMISTRY
  申请人：Ying Jackie Y.

  公开号：US20100105544A1

  公开（公告）日：2010-04-29

  The present invention relates to a method for preparing a heterogenised catalyst, comprising grafting a catalyst or catalyst precursor, via click chemistry, to a siliceous mesocellular foam (MCF). The invention also relates to a heterogenised catalyst comprising a catalyst species grafted onto a siliceous mesocellular foam (MCF) via a 1,2,3-triazole