5-bromo-4-phenylthiazole | 59278-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-bromo-4-phenylthiazole
• 英文别名: 5-bromo-4-phenyl-1,3-thiazole
• CAS: 59278-68-1
• 化学式: C₉H₆BrNS
• 分子量: 240.123
• InChiKey: QFARJSULJPZIFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-溴-4-苯基-2-噻唑胺 生成 5-bromo-4-phenylthiazole
  参考文献：
  名称：

  BOSCO M.; FORLANI L.; TODESCO P. E.; TROISI L., J. CHEM. SOC. PERKIN TRANS., PART 2 , 1976, NO 4, 398-402

  摘要：

  DOI：

文献信息

• TGF-Beta Inhibitors
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20160257690A1

  公开（公告）日：2016-09-08

  Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R 1 and R′ are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-β, and can be used to treat disease by blocking TGF-β signaling.

  本文披露了咪唑和噻唑化合物，以及其药物组合物和使用方法。一个实施例是具有以下结构的化合物 及其药用可接受盐、前药和N-氧化物（以及其溶剂和水合物），其中X、A、Z、R1和R'如本文所述。在某些实施例中，本文披露的化合物抑制TGF-β，并可用于通过阻断TGF-β信号传导来治疗疾病。
• NaBH4-TMEDA and a palladium catalyst as efficient regio- and chemoselective system for the hydrodehalogenation of halogenated heterocycles
  作者：Giorgio Chelucci、Susanna Figus

  DOI：10.1016/j.molcata.2014.06.012

  日期：2014.11
• Room-Temperature Hydrodehalogenation of Halogenated Heteropentalenes with One or Two Heteroatoms
  作者：Giorgio Chelucci、Salvatore Baldino、Andrea Ruiu

  DOI：10.1021/jo3019335

  日期：2012.11.2

  The pair NaBH4-TMEDA as a hydride source and catalytic PdCl2(4ppf) in THF prove to be an efficient system for the hydrodehalogenation of bromo(chloro)-heteropentalenes. with one or two heteroatoms, while Pd(OAc)(2)/PPh3 is able to reduce reactive haloheteropentalenes, and PdCl2(tbpf) allows the removal of the 2-chlorine from a thiophene ring. The reaction conditions tolerate various functional groups, allowing highly chemoselective reactions in the presence of halide, ester, alkyne, alkene, and nitrile substituents and also showing good efficiency in the regioselective hydrodehalogenation of a variety of polyhalogenated substrates.
• US9884868B2
  申请人：——

  公开号：US9884868B2

  公开（公告）日：2018-02-06