(4S,5R)-3-[3-(furan-2-yl)propanoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one | 311804-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4S,5R)-3-[3-(furan-2-yl)propanoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one
• CAS: 311804-05-4
• 化学式: C₁₇H₁₇NO₄
• 分子量: 299.326
• InChiKey: ZOTJPHNDSUOGCX-LRDDRELGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  59.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4S,5R)-3-[3-(furan-2-yl)propanoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one 在 lithium hydroxide 、 双氧水 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 生成 (R)-4-(tert-butoxy)-2-(furan-2-ylmethyl)-4-oxobutanoic acid
  参考文献：
  名称：

  Heteroaromatic side-chain analogs of pregabalin

  摘要：

  A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.090
• 作为产物：
  描述：

  2-呋喃丙酸乙酯 在 lithium hydroxide 、 TEA 、 三甲基乙酰氯 、 lithium chloride 作用下， 以 四氢呋喃 、 异丙醇 为溶剂， 生成 (4S,5R)-3-[3-(furan-2-yl)propanoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one
  参考文献：
  名称：

  Heteroaromatic side-chain analogs of pregabalin

  摘要：

  A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.090

文献信息

• ３−ヘテロアリールアルキル置換ＧＡＢＡ類似体
  申请人：——

  公开号：JP2003500486A

  公开（公告）日：2003-01-07

  \n (57)【要約】\n本発明は、てんかん、気絶発作、神経変性障害、うつ病、不安、パニック、痛み、神経病理的障害、胃腸障害、例えば過敏性腸症候群（ＩＢＳ）および炎症、特に関節炎の治療に有用な一連の新規化合物である。本発明の化合物を含有する医薬組成物、ならびにこれらの化合物の製造方法、最終化合物の製造に有用な新規中間体を包含する。\n

  \(57) [Abstract] The invention is a series of novel compounds useful in the treatment of epilepsy, fainting spells, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders, e.g. irritable bowel syndrome (IBS) and inflammation, particularly arthritis.含有本发明化合物的药物组合物，以及生产这些化合物的方法，包括对生产最终化合物有用的新中间体。\n
• 3-HETEROARYLALKYL SUBSTITUTED GABA ANALOGS
  申请人：Warner-Lambert Company LLC

  公开号：EP1185524B1

  公开（公告）日：2005-01-26
• [EN] 3-HETEROARYLALKYL SUBSTITUTED GABA ANALOGS<br/>[FR] ANALOGUES DE GABA SUBSTITUES PAR 3-HETEROARYLALKYLE
  申请人：WARNER LAMBERT CO

  公开号：WO2000073296A2

  公开（公告）日：2000-12-07

  The invention is a novel series of compounds which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.
• Heteroaromatic side-chain analogs of pregabalin
  作者：Robert M. Schelkun、Po-wai Yuen、David J. Wustrow、Jack Kinsora、Ti-Zhi Su、Mark G. Vartanian

  DOI：10.1016/j.bmcl.2005.06.090

  日期：2006.5

  A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein. (C) 2005 Elsevier Ltd. All rights reserved.