2-oxo-4-(3-phenylpropylamino)-1H-quinoline-3-carboxylic acid | 1296830-61-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-oxo-4-(3-phenylpropylamino)-1H-quinoline-3-carboxylic acid
• CAS: 1296830-61-9
• 化学式: C₁₉H₁₈N₂O₃
• 分子量: 322.364
• InChiKey: FETDLIFWLQEEIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-苯基-1-丙胺 、 4-氯-2-氧代-1H-喹啉-3-羧酸 在 三乙胺 作用下， 以 乙醇 为溶剂， 以84%的产率得到2-oxo-4-(3-phenylpropylamino)-1H-quinoline-3-carboxylic acid
  参考文献：
  名称：

  4-Hydro-2-quinolones. 192.* relationship of xy structure and analgesic activity of 4-amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives

  摘要：

  Some 4-N-R-2-Oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives were synthesized as close structural analogs of the highly-active analgesic 4-benzylamino-2-oxo-1,2-dihydroquinoline-carboxylic acid. Pharmacological testing showed that manifestation of an analgesic effect depends on the presence of a carboxylic group and benzyl fragment in these molecules.

  DOI：

  10.1007/s10593-011-0674-7

文献信息

• 4-Hydro-2-quinolones. 192.* relationship of xy structure and analgesic activity of 4-amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives
  作者：I. V. Ukrainets、E. V. Mospanova、A. A. Davidenko、S. V. Shishkina

  DOI：10.1007/s10593-011-0674-7

  日期：2011.2

  Some 4-N-R-2-Oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives were synthesized as close structural analogs of the highly-active analgesic 4-benzylamino-2-oxo-1,2-dihydroquinoline-carboxylic acid. Pharmacological testing showed that manifestation of an analgesic effect depends on the presence of a carboxylic group and benzyl fragment in these molecules.