1-vinylidenespiro<5.4>decan-7-one | 110477-26-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-vinylidenespiro<5.4>decan-7-one
• 英文别名: 1-vinylidenespiro<4.5>decan-7-one；1-Ethenylidenespiro[4.5]decan-7-one
• CAS: 110477-26-4
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: BBZVZYYHAALHMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-乙氧基-2-环己烯-1-酮 在 二氯乙基铝 、 magnesium 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 17.0h， 生成 1-vinylidenespiro<5.4>decan-7-one
  参考文献：
  名称：

  Intramolecular cyclization of allyl- and propargylsilanes. The regio- and stereochemical outcome of the cyclization

  摘要：

  DOI：

  10.1021/jo00251a029

文献信息

• Intramolecular cyclizations of allyl- and propargylsilanes
  作者：Dieter Schinzer、Sándor Sólyom、Marion Becker

  DOI：10.1016/s0040-4039(00)94749-x

  日期：1985.1

  Allylsilanes of type 5 and propargylsilanes of type 13 undergo efficient cyclizations upon treatment with EtAlCl2 in toluene to afford stereoselectively functionalized hydrindanones of type 6 and spiro[4,5]decanes of type 14.

  在甲苯中用EtAlCl 2处理后，类型5的烯丙基硅烷和类型13的炔丙基硅烷会发生有效的环化反应，从而得到类型6的立体选择性官能化的氢化茚酮和类型14的螺[4,5]癸烷。
• Selective mono- and polymethylene homologations of copper reagents using (iodomethyl)zinc iodide
  作者：AchyuthaRao Sidduri、Michael J. Rozema、Paul Knochel

  DOI：10.1021/jo00062a010

  日期：1993.5

  A wide range of unsaturated aryl-, alkenyl-, alkynylcopper compounds can be selectively homologated by a methylene unit using (iodomethyl)zinc iodide or bis(iodomethyl)zinc. These reactions allow the generation of mixed allylic zinc-copper compounds which can be efficiently trapped with carbonyl compounds. An application to a general preparation of functionalized alpha-methylene-gamma-butyrolactones is described. The homologation of alkynylcoppers with (iodomethyl)zinc iodide allows a one-pot preparation of propargylic copper reagents which in the presence of a carbonyl compound provide various homopropargylic alcohols in excellent yields. In the absence of an electrophile, a clean quadruple methylene homologation of alkynylcoppers occurs to furnish dienic copper reagents. The homologation of other types of copper reagents is also possible, and carbanions at the alpha-position to amines as well as homoenolates of aldehydes or ketones can also be prepared by this method.
• Allenylradicals in carbocyclizations
  作者：Frank-Hardi Wartenberg、Heiko Junga、Siegfried Blechert

  DOI：10.1016/s0040-4039(00)73965-7

  日期：1993.8

  Allenylic radicals, prepared from propargylic precursors, have been shown to cyclize diastereoselectively to vinylidene-substituted cyclopentanes.
• SCHINZER, D.;SOLYOM, S.;BECKER, M., TETRAHEDRON LETT., 1985, 26, N 15, 1831-1834
  作者：SCHINZER, D.、SOLYOM, S.、BECKER, M.

  DOI：——

  日期：——
• SCHINZER, DIETER;DETTMER, GERLINDE;RUPPELT, MARTIN;SOLYOM, SANDOR;STEFFEN+, J. ORG. CHEM., 53,(1988) N 16, C. 3823-3828
  作者：SCHINZER, DIETER、DETTMER, GERLINDE、RUPPELT, MARTIN、SOLYOM, SANDOR、STEFFEN+

  DOI：——

  日期：——