2-[(2-Aminophenyl)sulfanyl]-3-(4-nitrophenyl)-1-phenylpropan-1-one | 554436-19-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-[(2-Aminophenyl)sulfanyl]-3-(4-nitrophenyl)-1-phenylpropan-1-one
• 英文别名: 2-(2-aminophenyl)sulfanyl-3-(4-nitrophenyl)-1-phenylpropan-1-one
• CAS: 554436-19-0
• 化学式: C₂₁H₁₈N₂O₃S
• 分子量: 378.452
• InChiKey: LQPAWLNODPHPDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 、 2-氨基苯硫醇 在 fluorapatite 作用下， 以 甲醇 为溶剂， 反应 0.03h， 生成 2-[(2-Aminophenyl)sulfanyl]-3-(4-nitrophenyl)-1-phenylpropan-1-one 、 3-(2-amino-phenylsulfanyl)-3-(4-nitrophenyl)-1-phenyl-propan-1-one
  参考文献：
  名称：

  Fluorapatite: efficient catalyst for the Michael addition

  摘要：

  A Michael addition assisted by fluorapatite in heterogeneous media is described. Reaction between mercaptans and chalcone derivatives was studied at room temperature in methanol as solvent. By-products of usual undesirable reactions in Michael addition such as 1,2-addition, bis-addition and polymerisation are not observed. The yields obtained are good to excellent. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00323-x

文献信息

• Fluorapatite: efficient catalyst for the Michael addition
  作者：Mohamed Zahouily、Younes Abrouki、Ahmed Rayadh、Saı̈d Sebti、Hamid Dhimane、Marc David

  DOI：10.1016/s0040-4039(03)00323-x

  日期：2003.3

  A Michael addition assisted by fluorapatite in heterogeneous media is described. Reaction between mercaptans and chalcone derivatives was studied at room temperature in methanol as solvent. By-products of usual undesirable reactions in Michael addition such as 1,2-addition, bis-addition and polymerisation are not observed. The yields obtained are good to excellent. (C) 2003 Elsevier Science Ltd. All rights reserved.