Phenylalanyl-glycinanhydrid | 62107-97-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Phenylalanyl-glycinanhydrid
• 英文别名: (2-aminoacetyl) (2S)-2-amino-3-phenylpropanoate
• CAS: 62107-97-5
• 化学式: C₁₁H₁₄N₂O₃
• 分子量: 222.244
• InChiKey: DNXKBJVLPRMYJI-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  95.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Phenylalanyl-glycinanhydrid 在 钯 氢气 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 生成
  参考文献：
  名称：

  Optical resolution of N-carbobenzoxy-α-methoxyglycine

  摘要：

  Optical resolution of racemic N-carbobenzoxy-alpha-methoxyglycine using D/L-phenylalaninol or (1S,2S)-2-amino-1-phenyl-1,3-propanediol afforded (+)- and (-)-enantiomers, to which D- and L-configurations, respectively, were assigned based on the H-1 NMR data and biological activity of dermorphin N-terminal tetrapeptide analogs.

  DOI：

  10.1016/s0957-4166(00)86033-4
• 作为产物：
  描述：

  S-phenyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanethioate 在 溶剂黄146 、 三氟乙酸 作用下， 反应 2.0h， 生成 Phenylalanyl-glycinanhydrid
  参考文献：
  名称：

  Weygand,F.; Steglich,W., Chemische Berichte, 1960, vol. 93, p. 2983 - 3005

  摘要：

  DOI：

文献信息

• COMPOSITION FOR RELIEVING SUBJECTIVE SYMPTOMS OF FATIGUE
  申请人：Komatsu Miho

  公开号：US20090232917A1

  公开（公告）日：2009-09-17

  There has been a demand in the marketplace for medicines, functional foods and so on which can relieve subjective symptoms of fatigue in persons having these subjective symptoms, and enabling the persons to have productive days. That is, an object of the present invention is to provide a composition for relieving subjective symptoms of fatigue. According to the present invention, a safe and effective composition for relieving subjective symptoms of fatigue which contains ornithine or a salt thereof as an active ingredient can be provided.

  市场上对于能够缓解疲劳的药物、功能性食品等的需求越来越大，这些产品可以缓解那些有疲劳感的人的主观症状，帮助他们拥有高效的日子。因此，本发明的目的是提供一种缓解疲劳的组合物。根据本发明，可以提供一种安全有效的缓解疲劳的组合物，其包含鸟氨酸或其盐为活性成分。
• Oral medicament for improvement in going to sleep or waking
  申请人：Kamiya Toshikazu

  公开号：US20060258746A1

  公开（公告）日：2006-11-16

  A person, who has symptoms including difficulty in going to sleep, feeling languid after waked up or having a hard time awaking, is desirous of a medicament and a nutritional food that can alleviate the symptoms and improve his or her health. Specifically, one object of the present invention is to provide an orally administered agent, a food and drink, or a food additive which can be used for improving the process of going to sleep and waking. An orally administered agent, a food and drink, or a food additive for improving the process of going to sleep and waking, containing ornithine or a salt thereof as an active ingredient can be provided according to the present invention.

  一个人，他的症状包括入睡困难，醒来后感到疲倦或者醒来很困难，他渴望一种药物和营养食品，可以缓解症状并改善他的健康。具体而言，本发明的一个目标是提供一种口服制剂、食品和饮料或食品添加剂，可用于改善入睡和醒来的过程。根据本发明，可以提供一种口服制剂、食品和饮料或食品添加剂，其含有鸟氨酸或其盐作为活性成分，用于改善入睡和醒来的过程。
• Dipeptide derivatives of 7-(N-alpha-substituted or non-substituted X-arginyl)-amino-4-methyl-coumarin
  申请人：AJINOMOTO CO., INC.

  公开号：EP0000063A1

  公开（公告）日：1978-12-20

  7-(Na-substituted or non-substituted-X- arginyl)-amino-4- methyl-courmarin wherein X is the residue of an amino acid selected from the group of glycine, phenylalanine and proline and the acid salts thereof were prepared and found to be useful as fluorogenic substrates for determining enzymatic activities.

  制备了 7-(Na-取代或非取代-X-精氨酰)-氨基-4-甲基香豆素（其中 X 是选自甘氨酸、苯丙氨酸和脯氨酸组的氨基酸残基）及其酸盐，并发现它们可用作测定酶活性的荧光底物。
• Method for producing of phthalocyanine compound
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0882768A2

  公开（公告）日：1998-12-09

  A method for producing a novel phthalocyanine compound which excels in yield and purity, allows no introduction of a chlorine atom into the phthalocyanine skeleton, and possesses relatively bulky substituents is provided. This method is characterized by causing an orthophthalonitrile compound having a substituent exhibiting smaller σp values than σm values in the Hammett's rule to react with a metal oxide in the presence of a compound forming in the aqueous solution thereof at 25°C an acid or conjugate acid having a dissociation index pKa (the logarithmic value of the reciprocal of the dissociation constant of the acid or conjugate acid) of not more than 7.0.

  本发明提供了一种生产新型酞菁化合物的方法，该方法产量高、纯度高，不允许在酞菁骨架中引入氯原子，并具有相对笨重的取代基。 该方法的特点是，在 25°C 时，在其水溶液中形成的酸或共轭酸的化合物存在下，使具有取代基的 σp 值小于哈密特规则中的σm 值的邻苯二甲腈化合物与金属氧化物反应，该酸或共轭酸的离解指数 pKa（酸或共轭酸的离解常数倒数的对数值）不大于 7.0。
• COMPOSITION FOR RELIEVING SUBJECTIVE SYMPTOMS OF FATIGUE
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1935418A1

  公开（公告）日：2008-06-25

  There have been required medicines, functional foods and so on that can relieve subjective symptoms of fatigue in persons having these subjective symptoms and enables the persons to have productive days. That is, an object of the present invention is to provide a composition for relieving subjective symptoms of fatigue. According to the present invention, a safe and effective composition for relieving subjective symptoms of fatigue which contains ornithine or a salt thereof as an active ingredient can be provided.

  一直以来，人们需要能够缓解具有这些主观疲劳症状的人的主观疲劳症状的药物、功能性食品等，并使这些人能够过上富有成效的日子。也就是说，本发明的目的是提供一种用于缓解疲劳主观症状的组合物。根据本发明，可以提供一种安全有效的用于缓解疲劳主观症状的组合物，该组合物含有鸟氨酸或其盐作为活性成分。