2-溴-N-[2-[(2,5-二氧代-1-吡咯烷基)氧基]-2-氧代乙基]-乙酰胺 | 93801-73-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-溴-N-[2-[(2,5-二氧代-1-吡咯烷基)氧基]-2-氧代乙基]-乙酰胺
• 英文名称: bromoacetylglycyne N-hydroxysuccinimide ester
• 英文别名: N-(bromoacetamidoacetoxy)succinimide；bromoacetylglycine N-hydroxy succinimide；bromoacetylglycine N-hydroxysuccinimide ester；Succinimidyl-2-(bromoacetamido)acetate；(2,5-dioxopyrrolidin-1-yl) 2-[(2-bromoacetyl)amino]acetate
• CAS: 93801-73-1
• 化学式: C₈H₉BrN₂O₅
• 分子量: 293.074
• InChiKey: ZEYHJJIGNLVTLZ-UHFFFAOYSA-N

物化性质

• 密度：
  1.77±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  92.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2925190090

反应信息

• 作为反应物：
  描述：

  (5alpha)-3,14-二羟基-4,5-环氧吗喃-6-酮盐酸盐(1:1) 、 2-溴-N-[2-[(2,5-二氧代-1-吡咯烷基)氧基]-2-氧代乙基]-乙酰胺 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.83h， 以19.3%的产率得到
  参考文献：
  名称：

  [EN] CONJUGATES FOR ASSAYS FOR OXYCODONE AND OXYMORPHONE
  [FR] CONJUGUÉS UTILISABLES EN VUE DU DOSAGE DE L'OXYCODONE ET DE L'OXYMORPHONE

  摘要：

  公开号：

  WO2016100113A3
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 bromoacetylglycine 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以58%的产率得到2-溴-N-[2-[(2,5-二氧代-1-吡咯烷基)氧基]-2-氧代乙基]-乙酰胺
  参考文献：
  名称：

  Controlled coupling of aminoglycoside antibiotics to proteins for use in homogeneous enzyme immunoassays

  摘要：

  氨基糖苷抗生素的选择性N-酰化，使用甲基二硫乙酸的N-羟基琥珀酰亚胺酯，随后与甲硫醇或二硫巴比妥醇反应，可制备含硫巯基标记的抗生素。或者，通过与N-乙酰-d,l-同型半胱氨酸硫内酯处理，将亲核硫巯基基团引入抗生素中。这些衍生物可与之前用溴乙酰甘氨酰基修饰过的蛋白质轻松偶联，用于开发均相酶免疫分析的共轭物。

  DOI：

  10.1139/v84-425

文献信息

• [EN] ASSAY FOR ENTACTOGENS<br/>[FR] ESSAI D'ENTACTOGENES
  申请人：DADE BEHRING INC

  公开号：WO2005058864A1

  公开（公告）日：2005-06-30

  Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4­methylenedioxyamphetamine (MDA)3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-ethylamphetamine (MDEA) and 4-hydroxy-3-methoxy­methamphetamine (HMMA). The method comprises providing in combination in a medium (i) a sample suspected of containing the compound and (ii) an antibody raised against a compound of Formula I that comprises a protein. The medium is examined for the presence a complex comprising the compound and the antibody where the presence of such as complex indicates the presence of the compound in the sample. In one aspect of the above embodiment, the combination further comprises a label conjugate of the compound Formula I.

  揭示了方法、组合物和试剂盒。这些方法旨在确定致幻药物分析物的存在，例如3,4-亚甲二氧苯丙胺（MDA）、3,4-亚甲二氧甲基苯丙胺（MDMA）、3,4-亚甲二氧乙基苯丙胺（MDEA）和4-羟基-3-甲氧基苯丙胺（HMMA）。该方法包括在介质中组合提供（i）疑似含有该化合物的样品和（ii）针对包含蛋白质的化合物的I式的抗体。检查介质是否存在包含该化合物和抗体的复合物，其中这种复合物的存在表明样品中存在该化合物。在上述实施例的一个方面，该组合进一步包括化合物I式的标记结合物。
• Controlled coupling of aminoglycoside antibiotics to proteins for use in homogeneous enzyme immunoassays
  作者：Prithipal Singh、Marcel Pirio、Danton K. Leung、Yuh-Geng Tsay

  DOI：10.1139/v84-425

  日期：1984.11.1

  Selective N-acylation of aminoglycoside antibiotics with the N-hydroxysuccinimide ester of methyldithioacetic acid, followed by reaction with methanethiol or dithioerythritol, gives sulfhydryl labeled antibiotics. Alternatively, the nucleophilic sulfhydryl group is incorporated into an antibiotic by treatment with N-acetyl-d,l-homocysteine thiolactone. These derivatives couple readily with proteins that have previously been modified with bromoacetylglycyl groups to provide conjugates for use in the development of homogeneous enzyme immunoassays.

  氨基糖苷抗生素的选择性N-酰化，使用甲基二硫乙酸的N-羟基琥珀酰亚胺酯，随后与甲硫醇或二硫巴比妥醇反应，可制备含硫巯基标记的抗生素。或者，通过与N-乙酰-d,l-同型半胱氨酸硫内酯处理，将亲核硫巯基基团引入抗生素中。这些衍生物可与之前用溴乙酰甘氨酰基修饰过的蛋白质轻松偶联，用于开发均相酶免疫分析的共轭物。
• [EN] ASSAYS FOR AMPHETAMINE AND METHAMPHETAMINE<br/>[FR] ANALYSES VISANT A DETECTER LA PRESENCE D'AMPHETAMINE ET DE METHAMPHETAMINE
  申请人：DADE BEHRING INC

  公开号：WO2005092831A1

  公开（公告）日：2005-10-06

  Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. The distance of the amphetamine moiety and the methamphetamine moiety from the point of linkage of the second linking group to the first linking group is approximately the same. The compounds may be linked to labels and used in assays for the detection of amphetamine and/or methamphetamine in samples suspected of containing these drugs.

  本文介绍了方法、组合物和试剂盒。所述化合物包括由第一连接基连接在一起的苯丙胺基团和甲基苯丙胺基团。第二连接基从第一连接基依赖并包括一个功能基团。苯丙胺基团和甲基苯丙胺基团距离第二连接基与第一连接基连接点的距离大致相同。这些化合物可以与标签连接并用于检测样品中可能含有苯丙胺和/或甲基苯丙胺的测定中。
• Immunoassays for buprenorphine and norbuprenorphine
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：EP2264464A2

  公开（公告）日：2010-12-22

  Methods, compositions and kits are disclosed directed at haptens, immunogens and immnoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination in a medium (i) a sample suspected of containing buprenorphine (BUP) or norbuprenorphine (norBUP) and (ii) an antibody raised against an immunogen of buprenorphine (BUP) or norbuprenorphine (norBUP). The medium is examined for the presence of a complex comprising a labeled hapten of buprenorphine (BUP) or norbuprenorphine (norBUP) where the presence of such as complex indicates the presence of the compound in the sample.

  本发明公开了针对丁丙诺啡（BUP）和诺丁诺啡（norBUP）的抗原、免疫原和免疫测定方法、组合物和试剂盒。该方法包括在培养基中结合提供 (i) 怀疑含有丁丙诺啡（BUP）或诺丁诺啡（norBUP）的样品和 (ii) 针对丁丙诺啡（BUP）或诺丁诺啡（norBUP）免疫原的抗体。检查培养基中是否存在由丁丙诺啡（BUP）或诺丁诺啡（norBUP）的标记杂合体组成的复合物，存在这种复合物表明样品中存在化合物。
• Conjugates for assays for oxycodone and oxymorphone
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：US10351830B2

  公开（公告）日：2019-07-16

  Compositions, methods, and kits are disclosed directed at haptens, immunogens and immunoassays for oxycodone and metabolites thereof. The compounds are exemplified by compounds of the Formula I. The method comprises providing in combination in a medium (i) a sample suspected of containing oxycodone and/or oxycodone metabolites, a compound of the Formula I wherein R4 or R5 is a label, and an antibody for oxycodone or a metabolite thereof. The medium is examined for the presence of a complex comprising the labeled compound of Formula I where the presence of such as complex indicates the presence of oxycodone or oxycodone metabolite in the sample.

  本发明公开了针对羟考酮及其代谢物的触媒、免疫原和免疫测定的组合物、方法和试剂盒。这些化合物以式 I 的化合物为例。该方法包括在培养基中结合提供 (i) 疑似含有羟考酮和/或羟考酮代谢物的样品、式 I 化合物（其中 R4 或 R5 是标记）和羟考酮或其代谢物的抗体。检测培养基中是否存在由式 I 标记化合物组成的复合物，复合物的存在表明样本中存在羟考酮或羟考酮代谢物。