Acetic acid (2R,3R,4R)-4,5-diacetoxy-2-[(S)-2-acetoxy-1-((2S,3R,4R,5R)-3,4-diacetoxy-5-azidomethyl-tetrahydro-furan-2-yloxy)-ethyl]-tetrahydro-furan-3-yl ester | 302917-34-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetic acid (2R,3R,4R)-4,5-diacetoxy-2-[(S)-2-acetoxy-1-((2S,3R,4R,5R)-3,4-diacetoxy-5-azidomethyl-tetrahydro-furan-2-yloxy)-ethyl]-tetrahydro-furan-3-yl ester
• CAS: 302917-34-6
• 化学式: C₂₃H₃₁N₃O₁₅
• 分子量: 589.51
• InChiKey: OFEATAXKIYKTHC-ZGYRBQMUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.02
• 重原子数：
  41.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  234.25
• 氢给体数：
  0.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  Acetic acid (2R,3R,4R)-4,5-diacetoxy-2-[(S)-2-acetoxy-1-((2S,3R,4R,5R)-3,4-diacetoxy-5-azidomethyl-tetrahydro-furan-2-yloxy)-ethyl]-tetrahydro-furan-3-yl ester 在 甲醇 、 三氟甲磺酸三甲基硅酯 、 水 、 sodium methylate 、 三苯基膦 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成 1-{(2R,3R,4S,5S)-5-[(S)-1-((2S,3R,4S,5R)-5-Aminomethyl-3,4-dihydroxy-tetrahydro-furan-2-yloxy)-2-hydroxy-ethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis of the Nucleoside Moiety of Liposidomycins: Elucidation of the Pharmacophore of this Family of MraY Inhibitors

  摘要：

  Tunicamycins (TCMs) and liposidomycins (LPMs) are naturally occurring inhibitors of the bacterial translocase (MraY). Based on structure-activity relationship (SAR) studies, a molecular model has been proposed for their inhibitory mechanism. This study points out the importance of the nucleoside moiety of liposidomycins in the inhibition of MraY. A simplified molecule (I) based on the liposidomycin core structure has been synthesised and tested on MraY. The compound displayed a moderate inhibitory activity (IC50-50 mu M). The validation of the molecular model was then performed by synthesising higher homologues of I, containing an additional stereocentre in the 5' position (XIV and XV). In agreement with the prediction, only the (S) isomer XV showed significant activity against MraY (IC50=5 mu M). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00349-8
• 作为产物：
  描述：

  乙酸酐 、 在 吡啶 作用下， 生成 Acetic acid (2R,3R,4R)-4,5-diacetoxy-2-[(S)-2-acetoxy-1-((2S,3R,4R,5R)-3,4-diacetoxy-5-azidomethyl-tetrahydro-furan-2-yloxy)-ethyl]-tetrahydro-furan-3-yl ester
  参考文献：
  名称：

  Synthesis of the Nucleoside Moiety of Liposidomycins: Elucidation of the Pharmacophore of this Family of MraY Inhibitors

  摘要：

  Tunicamycins (TCMs) and liposidomycins (LPMs) are naturally occurring inhibitors of the bacterial translocase (MraY). Based on structure-activity relationship (SAR) studies, a molecular model has been proposed for their inhibitory mechanism. This study points out the importance of the nucleoside moiety of liposidomycins in the inhibition of MraY. A simplified molecule (I) based on the liposidomycin core structure has been synthesised and tested on MraY. The compound displayed a moderate inhibitory activity (IC50-50 mu M). The validation of the molecular model was then performed by synthesising higher homologues of I, containing an additional stereocentre in the 5' position (XIV and XV). In agreement with the prediction, only the (S) isomer XV showed significant activity against MraY (IC50=5 mu M). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00349-8