methyl 3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(2-cyclopentylacetamido)propanoate | 1262632-76-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(2-cyclopentylacetamido)propanoate
• CAS: 1262632-76-7
• 化学式: C₂₅H₃₆N₂O₄S₂
• 分子量: 492.704
• InChiKey: IQYAJELRIXXOQD-KEKNWZKVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.12
• 重原子数：
  33.0
• 可旋转键数：
  12.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  84.5
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  methyl 3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(2-cyclopentylacetamido)propanoate 在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(2-cyclopentylacetamido)-propanoic acid
  参考文献：
  名称：

  Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array

  摘要：

  We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.

  DOI：

  10.1021/ja108527y
• 作为产物：
  描述：

  Thioctic acid 在 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 生成 methyl 3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(2-cyclopentylacetamido)propanoate
  参考文献：
  名称：

  Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array

  摘要：

  We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.

  DOI：

  10.1021/ja108527y