(S)-methyl 2-(2-cyclopentylacetamido)-3-(4-nitrophenyl)propanoate | 1262632-71-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-methyl 2-(2-cyclopentylacetamido)-3-(4-nitrophenyl)propanoate
• 英文别名: methyl (2S)-2-[(2-cyclopentylacetyl)amino]-3-(4-nitrophenyl)propanoate
• CAS: 1262632-71-2
• 化学式: C₁₇H₂₂N₂O₅
• 分子量: 334.372
• InChiKey: NKHBKLJUUDCOSC-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (S)-methyl 2-(2-cyclopentylacetamido)-3-(4-nitrophenyl)propanoate 在 水 、 溶剂黄146 、 三乙胺 、 lithium hydroxide 、 锌 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 生成 3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(2-cyclopentylacetamido)-propanoic acid
  参考文献：
  名称：

  Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array

  摘要：

  We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.

  DOI：

  10.1021/ja108527y
• 作为产物：
  描述：

  环戊基乙酰氯 、 (S)-4-硝基苯丙氨酸甲酯 在 三乙胺 作用下， 生成 (S)-methyl 2-(2-cyclopentylacetamido)-3-(4-nitrophenyl)propanoate
  参考文献：
  名称：

  Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array

  摘要：

  We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.

  DOI：

  10.1021/ja108527y

文献信息

• Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array
  作者：Hongyu Zhou、Peifu Jiao、Lei Yang、Xi Li、Bing Yan

  DOI：10.1021/ja108527y

  日期：2011.2.2

  We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.